{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guillot-Delost M"],"funding":["European Research Council"],"pagination":["e1179414"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5006899"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(7)"],"pubmed_abstract":["Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine expressed by epithelial cells during allergic inflammation, and activating dendritic cells (DC). Its expression and functional role in cancer remain controversial. We conducted retrospective (n = 89), and prospective studies including patients with untreated primary head and neck squamous cell carcinoma (HNSCC). We found that TSLP was overexpressed by HNSCC tumor cells, and associated with a highly differentiated status. However, no significant difference in overall and recurrence-free survival was found between patients bearing a tumor with high and low TSLP levels, respectively. Surprisingly, there was no significant association between the levels of TSLP expression, and the number of tumor-infiltrating mature DCL"],"journal":["Oncoimmunology"],"pubmed_title":["Ligand-receptor dissociated expression explains high TSLP without prognostic impact in human primary head and neck squamous cell carcinoma."],"pmcid":["PMC5006899"],"funding_grant_id":["281987"],"pubmed_authors":["Scholer-Dahirel A","Sastre-Garau X","Kebir FZ","Rodriguez J","Tartour E","Honorio S","Le Tourneau C","Mosseri V","Pattarini L","Huerre M","Nicolas A","Lappartient E","Le Peltier N","Michea P","Sablin MP","Berger F","Ventre A","Soumelis V","Klijanienko J","Jouffroy T","Sirven P","Badoual C","Guillot-Delost M","Guillere L","Chouchane-Mlik O"],"additional_accession":[]},"is_claimable":false,"name":"Ligand-receptor dissociated expression explains high TSLP without prognostic impact in human primary head and neck squamous cell carcinoma.","description":"Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine expressed by epithelial cells during allergic inflammation, and activating dendritic cells (DC). Its expression and functional role in cancer remain controversial. We conducted retrospective (n = 89), and prospective studies including patients with untreated primary head and neck squamous cell carcinoma (HNSCC). We found that TSLP was overexpressed by HNSCC tumor cells, and associated with a highly differentiated status. However, no significant difference in overall and recurrence-free survival was found between patients bearing a tumor with high and low TSLP levels, respectively. Surprisingly, there was no significant association between the levels of TSLP expression, and the number of tumor-infiltrating mature DCL","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jul","modification":"2025-06-01T01:07:29.93Z","creation":"2025-06-01T01:07:29.93Z"},"accession":"S-EPMC5006899","cross_references":{"pubmed":["27622034"],"doi":["10.1080/2162402X.2016.1179414","10.1080/2162402x.2016.1179414"]}}