biostudies-literatureUnknown90(18)Graf TFundação de Amparo à Pesquisa do Estado do Rio Grande do SulCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorMCTI | Conselho Nacional de Desenvolvimento Científico e TecnológicoFundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina<h4>Unlabelled</h4>The high incidence of AIDS cases and the dominance of HIV-1 subtype C infections are two features that distinguish the HIV-1 epidemic in the two southernmost Brazilian states (Rio Grande do Sul [RS] and Santa Catarina [SC]) from the epidemic in other parts of the country. Nevertheless, previous studies on HIV molecular epidemiology were conducted mainly in capital cities, and a more comprehensive understanding of factors driving this unique epidemic in Brazil is necessary. Blood samples were collected from individuals in 13 municipalities in the Brazilian southern region. HIV-1 env and pol genes were submitted to phylogenetic analyses for assignment of subtype, and viral population phylodynamics were reconstructed by applying Skygrid and logistic coalescent models in a BJournal of virology8160-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC5008080biostudies-literatureComprehensive Characterization of HIV-1 Molecular Epidemiology and Demographic History in the Brazilian Region Most Heavily Affected by AIDS.PMC5008080de Medeiros RMEsteves de Matos Almeida SMaletich Junqueira DPinto ARGraf TMachado Fritsch HfalseComprehensive Characterization of HIV-1 Molecular Epidemiology and Demographic History in the Brazilian Region Most Heavily Affected by AIDS.<h4>Unlabelled</h4>The high incidence of AIDS cases and the dominance of HIV-1 subtype C infections are two features that distinguish the HIV-1 epidemic in the two southernmost Brazilian states (Rio Grande do Sul [RS] and Santa Catarina [SC]) from the epidemic in other parts of the country. Nevertheless, previous studies on HIV molecular epidemiology were conducted mainly in capital cities, and a more comprehensive understanding of factors driving this unique epidemic in Brazil is necessary. Blood samples were collected from individuals in 13 municipalities in the Brazilian southern region. HIV-1 env and pol genes were submitted to phylogenetic analyses for assignment of subtype, and viral population phylodynamics were reconstructed by applying Skygrid and logistic coalescent models in a B2016-01-01T00:00:00Z2016 Sep2025-04-25T19:03:31.273Z2019-03-27T02:23:17ZS-EPMC50080802738466310.1128/jvi.00363-1610.1128/JVI.00363-16