biostudies-literatureMarzec JCancer Research UKEngineering and Physical Sciences Research Council21393-403https://www.ebi.ac.uk/biostudies/studies/S-EPMC5008293biostudies-literatureUnknown7(16)Prostate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated Chinese population, we performed single-nucleotide polymorphism (SNP) array analysis on a cohort of Chinese cases and controls and then meta-analysis with data from the existing Chinese prostate cancer genome-wide association study (GWAS). Genotyping 211,155 SNPs in 495 cases and 640 controls of Chinese ancestry identified several new suggestive Chinese prostate cancer predisposition loci. However, none of them reached genome-wide significance level either by meta-analysis or replication study. The meta-analysis with the Chinese GWAS data revealed that four 8q24 loci are the OncotargetA genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population.PMC5008293101181656315007175281225895Chelala CWu JCao GZhao SCZhang HWang GLu YJWang MRen GGuo JZhou BNeal DEEaston DFMao XBenlloch SKote-Jarai ZWu YYu YXu LEeles RAMarzec JLi JChen LCui XXu HZhou YLi MSun ZXu JXue YFeng NHou JOliver THong YZhang ZZhang YHe WYin CAl Olama AAZhang XRoss-Adams HGou XCHIPGECS GroupXu XPRACTICAL ConsortiumfalseA genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population.Prostate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated Chinese population, we performed single-nucleotide polymorphism (SNP) array analysis on a cohort of Chinese cases and controls and then meta-analysis with data from the existing Chinese prostate cancer genome-wide association study (GWAS). Genotyping 211,155 SNPs in 495 cases and 640 controls of Chinese ancestry identified several new suggestive Chinese prostate cancer predisposition loci. However, none of them reached genome-wide significance level either by meta-analysis or replication study. The meta-analysis with the Chinese GWAS data revealed that four 8q24 loci are the 2016-01-01T00:00:00Z2016 Apr2026-04-17T17:09:49.977Z2019-03-27T02:23:18ZS-EPMC50082932688139010.18632/oncotarget.7250