biostudies-literatureUnknown16(6)Sosa-Jurado F<h4>Background</h4>The hepatitis B virus (HBV) causes chronic hepatitis, hepatic cirrhosis, and hepatocellular carcinoma. Surface antigen (HBsAg) detection is a definitive test that can confirm HBV infection, while the presence of antibodies against the core protein (anti-HBc) suggests either a previous or ongoing infection or occult hepatitis B infection (OBI).<h4>Objectives</h4>The aim of the present study was to determine the prevalence of anti-HBc and HBsAg in blood donors. Further, the study aimed to estimate the anti-HBc level at which HBV DNA is detected in putative OBI cases, as well as to search for mutations in the "a" determinant associated with the non-detection of HBsAg in serum.<h4>Patients and methods</h4>We conducted a cross-sectional study from 2003-2009. The study includeHepatitis monthlye36942https://www.ebi.ac.uk/biostudies/studies/S-EPMC5011399biostudies-literaturePrevalence of Serologic Hepatitis B Markers in Blood Donors From Puebla, Mexico: The Association of Relatively High Levels of Anti-Core Antibodies With the Detection of Surface Antigen and Genomic DNA.PMC5011399Melendez-Mena DPerez Zempoaltecalt CGuzman-Flores BTeresa Lopez Delgado MMarquez-Dominguez LHilda Rosas-Murrieta NRamirez Rosete LPatricia Sanchez Torres ASosa-Jurado FVallejo-Ruiz VSantos-Lopez GBernal-Soto MReyes-Leyva JAngel Mendoza Torres MfalsePrevalence of Serologic Hepatitis B Markers in Blood Donors From Puebla, Mexico: The Association of Relatively High Levels of Anti-Core Antibodies With the Detection of Surface Antigen and Genomic DNA.<h4>Background</h4>The hepatitis B virus (HBV) causes chronic hepatitis, hepatic cirrhosis, and hepatocellular carcinoma. Surface antigen (HBsAg) detection is a definitive test that can confirm HBV infection, while the presence of antibodies against the core protein (anti-HBc) suggests either a previous or ongoing infection or occult hepatitis B infection (OBI).<h4>Objectives</h4>The aim of the present study was to determine the prevalence of anti-HBc and HBsAg in blood donors. Further, the study aimed to estimate the anti-HBc level at which HBV DNA is detected in putative OBI cases, as well as to search for mutations in the "a" determinant associated with the non-detection of HBsAg in serum.<h4>Patients and methods</h4>We conducted a cross-sectional study from 2003-2009. The study include2016-01-01T00:00:00Z2016 Jun2025-05-31T23:52:22.615Z2025-05-31T23:52:22.615ZS-EPMC50113992763072610.5812/hepatmon.36942