biostudies-literatureSkurnik DNIAID NIH HHS898-914https://www.ebi.ac.uk/biostudies/studies/S-EPMC5013867biostudies-literatureUnknown33(4)In the context of the great concern about the impact of human activities on the environment, we studied 403 commensal Escherichia coli/Escherichia clade strains isolated from several animal and human populations that have variable contacts to one another. Multilocus sequence typing (MLST) showed a decrease of diversity 1) in strains isolated from animals that had an increasing contact with humans and 2) in all strains that had increased antimicrobial resistance. A specific B1 phylogroup clonal complex (CC87, Institut Pasteur schema nomenclature) of animal origin was identified and characterized as being responsible for the increased antimicrobial resistance prevalence observed in strains from the environments with a high human-mediated antimicrobial pressure. CC87 strains have a high capacMolecular biology and evolutionEmergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans.PMC5013867R01 AI026289Mekalanos JDiancourt LPicard BPons SRoux DDanilchanka OClermont OLebreton FDenamur MTenaillon OAschard HSkurnik DDion SSchwarz SBrisse SGuillard TAndremont ADenamur EJiang DKadlec KCywes-Bentley CLaunay AfalseEmergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans.In the context of the great concern about the impact of human activities on the environment, we studied 403 commensal Escherichia coli/Escherichia clade strains isolated from several animal and human populations that have variable contacts to one another. Multilocus sequence typing (MLST) showed a decrease of diversity 1) in strains isolated from animals that had an increasing contact with humans and 2) in all strains that had increased antimicrobial resistance. A specific B1 phylogroup clonal complex (CC87, Institut Pasteur schema nomenclature) of animal origin was identified and characterized as being responsible for the increased antimicrobial resistance prevalence observed in strains from the environments with a high human-mediated antimicrobial pressure. CC87 strains have a high capac2016-01-01T00:00:00Z2016 Apr2025-04-21T18:58:05.575Z2019-03-27T02:23:38ZS-EPMC50138672661378610.1093/molbev/msv280