{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(9)"],"submitter":["Mendonca Belmont TF"],"pubmed_abstract":["<h4>Introduction</h4>Patients with sickle cell anemia (SCA) may present chronic hemolytic anemia, vaso-occlusion and respiratory tract infection (RTI) episodes. Galectin-3 (GAL-3) is a multifunctional protein involved in inflammation, apoptosis, adhesion and resistance to reactive oxygen species. Studies point to a dual role for GAL-3 as both a circulation damage-associated molecular pattern and a cell membrane associated pattern recognition receptor.<h4>Objective</h4>To investigate associations between the SNPs of GAL-3 gene (LGALS3) and serum levels with RTI and vaso-occlusive crisis (VOC) in children with SCA.<h4>Materials and methods</h4>SNPs +191 and +292 in LGALS3 were studied using the TaqMan real-time PCR system; GAL-3 serum levels were measured by ELISA. The study included 79 chil"],"journal":["PloS one"],"pagination":["e0162297"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5014331"],"repository":["biostudies-literature"],"pubmed_title":["Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia."],"pmcid":["PMC5014331"],"pubmed_authors":["Araujo Ada S","Cavalcanti Mdo S","Silva Vasconcelos LR","Silva Medeiros F","Soares da Silva A","do O KP","Bezerra MA","Mendonca Dos Anjos AC","de Melo Rego MJ","Domingues Hatzlhofer BL","de Melo Vilar K","Moura P","Mendonca Belmont TF","Pitta MG"],"additional_accession":[]},"is_claimable":false,"name":"Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia.","description":"<h4>Introduction</h4>Patients with sickle cell anemia (SCA) may present chronic hemolytic anemia, vaso-occlusion and respiratory tract infection (RTI) episodes. Galectin-3 (GAL-3) is a multifunctional protein involved in inflammation, apoptosis, adhesion and resistance to reactive oxygen species. Studies point to a dual role for GAL-3 as both a circulation damage-associated molecular pattern and a cell membrane associated pattern recognition receptor.<h4>Objective</h4>To investigate associations between the SNPs of GAL-3 gene (LGALS3) and serum levels with RTI and vaso-occlusive crisis (VOC) in children with SCA.<h4>Materials and methods</h4>SNPs +191 and +292 in LGALS3 were studied using the TaqMan real-time PCR system; GAL-3 serum levels were measured by ELISA. The study included 79 chil","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2026-04-30T03:42:39.016Z","creation":"2019-03-26T22:54:12Z"},"accession":"S-EPMC5014331","cross_references":{"pubmed":["27603703"],"doi":["10.1371/journal.pone.0162297"]}}