biostudies-literatureEBCTCG (Early Breast Cancer Trialists' Collaborative Group)British Heart FoundationCancer Research UKBreast Cancer NowMedical Research CouncilNational Institute for Health Research (NIHR)NCI NIH HHS2127-35https://www.ebi.ac.uk/biostudies/studies/S-EPMC5015598biostudies-literatureUnknown383(9935)<h4>Background</h4>Postmastectomy radiotherapy was shown in previous meta-analyses to reduce the risks of both recurrence and breast cancer mortality in all women with node-positive disease considered together. However, the benefit in women with only one to three positive lymph nodes is uncertain. We aimed to assess the effect of radiotherapy in these women after mastectomy and axillary dissection.<h4>Methods</h4>We did a meta-analysis of individual data for 8135 women randomly assigned to treatment groups during 1964-86 in 22 trials of radiotherapy to the chest wall and regional lymph nodes after mastectomy and axillary surgery versus the same surgery but no radiotherapy. Follow-up lasted 10 years for recurrence and to Jan 1, 2009, for mortality. Analyses were stratified by trial, individLancet (London, England)Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials.PMC5015598MC_U137686850ACF-2012-13-010G9600656NF-SI-0510-10026EDN-DIXONMC_U13768685816896NIHR-INF-0083U10 CA18083810588Cufer TJohansson UKilburn LCrossley EJanicke FGelman RSForsyth SHuovinen RYosef HMSmith DCDi Palma MAsmar LHarris JRUchino JRutgers EUntch MDouglas PThuerlimann BFisher BBartelink Hdi Blasio Baf Trampe EHackshaw ASonoo HSpooner DSoderberg MPerbeck LLythgoe JPAndre FKerbrat PPanzarella TKay RGZujewski JAFohler HRegan MMFentiman ISFredriksson IHolli KReinertsen KVilcoq JRRoche HGeyer CLarsimont DGettins LRossbach JLiedtke CNamer MLioce MThurlimann BLopez MCoates AGerber BStallard SMalmstrom PScheurlen HGoss PEHoughton JYamashita JMakris ABishop HWallwiener DAlbano JKwong DLForbes JFDi Leo AGreil Rvan Tinteren HPaik SSenanayake FTormey DCNogaret JMCarrasco EHicks CArriagada RBuyse MJensen MBIvanov VMartin ALGallen MKreienberg RKlefstrom PLehingue YMurray EKoyama HJones SESugimachi KMurray NMansel REBroadwater GPannuti FSohn HCFesl CEllis PCamerini TSteger GGMihura JBrockschmidt JInbar MJRedmond CPritchard KIGudgeon CASegui MABuzdar AUAbe OVeronesi UPeek Uvon Minckwitz GAbe RDunn JBurrett JAStoger HNordenskjold BShepherd LELiu HForrest PBrowne LGoldstein LJCrowley JAnderson SOwen JRMason BHTreurniet-Donker ADSwain SBryant AJNikolaidis PZhao DBSawa KBondesson TPerez EElphinstone PBrookes CSimmonds PDPellegrini FBoccardo FGelber RDSayer JJonat WOsborne CKWiner EGregory CTobias JSValagussa PAogi Kde la Huerta RLay MBijker NHarris AEiermann WUeo HBartsch RRobertson JFBelfiglio MAnderson HRotstein SWood WGelmon KVakaet LCosta AAbu-Zahra HTFountzilas GToi MAmadori DMargreiter RHoldaway IMSenn HJD'Amico CEwing GHCirrincione CWerner IDde Lafontan BJackisch CBlomqvist CMonson KBruzzi PStewart HJPirozzoli MCCoombes RCWittes RJackson IMSchmid PBowden SRomain SLevine MBrenner HFyles AOgawa Mdi Martino LKooi Mvan Dongen JAHauer-Jensen MBass GLiljegren GLitton AMouridsen HBroglio KCosta SDDi Mauro MGFocan CColozza AKissin MPribylova OPalshof TMeier PYoshida MEidtmann HSkilton DWallgren ACowan KTrampisch HJBusinico ABlohmer JUEllis IOPai VRMannu Gde Schryver AParidaens RBryant JPan HCCocconi GSevelda PLippman MBundred NJMartoni ASparano JABarlow WHercbergs AAltemus RRauschecker HDavis HLGeorge WDKikuchi KCarpenter JTLenner ESchumacher MMorimoto KJonsson HThomssen CClarke MEBCTCG (Early Breast Cancer Trialists' Collaborative Group)Del Mastro LLang AEnomoto KMauriac LLoibl SParulekar WPinder SMaibach RRea DLindman HBates TMasuda HWickerham LChapman JASakai KDavidson NELevine MNHudis CANeven PPaltuev RDe Placido SSertoli MRSaaristo RLuschin-Ebengreuth GDelaloge SPhilippson CPeretz TMichiels SVarhaug JEHacking APeto RRotmensz NBonneterre JPiccart MJvan Putten WLBastert GRudenstam CMSpittle MDelmestri AZielinski CCMcArdle CSHayward JLFormelli FMarkopoulos CBliss JDowsett MWilcken NMcHugh TWhelan TLove RRGianni LMackey JKunkler IMavroudis DEjlertsen BRubino CWilliams LHarbeck NDe Palo GHupperets PSFalkson CIPrice KNde La Lande BMeisner CLofgren LTaylor MMallon Evan de Velde AOAsselain BMouret-Fourme EJames SBrain EDurand MTaylor CCuzick JMace Lesech JTakatsuka YMlineritsch BKoscielny SPrice JJPoole CJoensuu HGralow JVermorken JBCamphausen KSandelin KForbes JRoyle GTErikstein BFohlin HRubagotti ALichter AViale GBarrett-Lee PJSchauer Avan de Velde CJKrushen-Kosloski JLDubois JBMustacchi GHermans DHall EMuss HLindtner JChilvers CENomura YLindtner APinder SEMitchell AKParton MDafni UGray RKaufmann MGiokas GSeifert MDeutsch GPA'Hern RGeraud PYarnold JRIsola JFumoleau PHsu LMathe GGodwin JDanforth DVenzon DParadiso AShapiro CLWadstrom CPierce LJBraun SGervasio HHakes TDahlberg KNitz UCutter DSauerbrei WMeyer RShan YHill CHolmberg LLivingston RMarth CSinger CFDarby SEvans VPatnick JTu DCarlomagno CHowell AParker DIkeda TGriffon BCollett VLinderholm BKOlivotto IBengtsson NOTominaga TGnant MFernando IMasood MBCanney PCastiglione MGoransson EAdolfsson JVan den Bogaert WAlbain KHayes DSaarto TJacobsen ABIngle JNMorris PPaterson AHChristiansen PRubens RDSvane GLedermann JIiristo MLeonard CFde Vries EGKlijn JGLuporsi ELissaios BHost HSteinberg SVenturini MDent DMCollins RPossinger KPronzato PChlebowski RTMcGale PBastiaannet ESkoog LMarty MSolin LJReid MSuman VJHannisdal EMonypenny IJCardoso FSalmon RJRouhento KCollins JKorzeniowski SSestak ISacco MGundersen SRagaz JHayat HChetty UDolci SFirth LATalbot DWarnberg FMartin PRyden LInokuchi KMartin MKerr Avan de Water WNorton LSainz MGGazet JCDubsky PStroner PSauer RCostantino JMorgan DAKillander FJulien JPNissen-Meyer RDavies KCalais GHenderson CMartino SDavies CEwertz MValentini MRavdin PMKarlsson PGordilho JMacKinnon EBenraadt JPalmer MKLee MRodenhuis SGluz OCorrea CShao YFDelozier TFornander TFrisell JPowell JCelebioglu FOates GDHaybittle JLKondylis DCarstensen JCorcoran NErazo ATakei HPowles TJSledge GColleoni MEmdin SOhashi YRomestaing PAhlgren JDeshpande NBlamey RWCaffier HMedina JYFargeot PBrown ADe Laurentiis MWeiss RBBaum MSchmitt MComis RLOhno SBergh JFoster LMamounas EPO'Shaughnessy JHarvey VJMoller SBogaerts JWang XYoshimoto MWang YSemiglazov VHortobagyi GWang ZGalligioni EDignam JSkolyszewski JJohansen HPater JLRobert NJanauer MHoriguchi JGraham PBerry DSmith IECamisa RDuane FPassalacqua RTinterri CGordon NHJack WCunningham MPWolmark NMeakin JWBliss JMHakama MDixon JMNotter GBorovik RPortnoj SMArnesson LGCameron DNicolucci ASamonigg HDalesio Ovan Nes JGGoldhirsch ASwindell RTakashima SHilfrich JGarmo HChen ZMBonadonna GJakesz RMouridsen HTPanieri ELindsay MAMisset JLCooper MRChristiaens RBahi Jde Oliveira CFDufmats MRobinson EPennert KJanni WPetruzelka LfalseEffect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials.<h4>Background</h4>Postmastectomy radiotherapy was shown in previous meta-analyses to reduce the risks of both recurrence and breast cancer mortality in all women with node-positive disease considered together. However, the benefit in women with only one to three positive lymph nodes is uncertain. We aimed to assess the effect of radiotherapy in these women after mastectomy and axillary dissection.<h4>Methods</h4>We did a meta-analysis of individual data for 8135 women randomly assigned to treatment groups during 1964-86 in 22 trials of radiotherapy to the chest wall and regional lymph nodes after mastectomy and axillary surgery versus the same surgery but no radiotherapy. Follow-up lasted 10 years for recurrence and to Jan 1, 2009, for mortality. Analyses were stratified by trial, individ2014-01-01T00:00:00Z2014 Jun2025-04-05T10:43:31.475Z2019-03-27T02:23:47ZS-EPMC50155982465668510.1016/S0140-6736(14)60488-8