biostudies-literatureHoppmann ASBundesministerium für Bildung und ForschungDeutsche ForschungsgemeinschaftSeventh Framework Programmee0162466https://www.ebi.ac.uk/biostudies/studies/S-EPMC5017755biostudies-literatureUnknown11(9)Genome-wide association studies (GWAS) evaluate associations between genetic variants and a trait or disease of interest free of prior biological hypotheses. GWAS require stringent correction for multiple testing, with genome-wide significance typically defined as association p-value <5*10-8. This study presents a new tool that uses external information about genes to prioritize SNP associations (GenToS). For a given list of candidate genes, GenToS calculates an appropriate statistical significance threshold and then searches for trait-associated variants in summary statistics from human GWAS. It thereby allows for identifying trait-associated genetic variants that do not meet genome-wide significance. The program additionally tests for enrichment of significant candidate gene associationsPloS oneGenToS: Use of Orthologous Gene Information to Prioritize Signals from Human GWAS.PMC5017755SFB 1140SFB 992KO 3598/3-1602300031 A538AFACELausch EKottgen ASchlosser PBackofen RHoppmann ASfalseGenToS: Use of Orthologous Gene Information to Prioritize Signals from Human GWAS.Genome-wide association studies (GWAS) evaluate associations between genetic variants and a trait or disease of interest free of prior biological hypotheses. GWAS require stringent correction for multiple testing, with genome-wide significance typically defined as association p-value <5*10-8. This study presents a new tool that uses external information about genes to prioritize SNP associations (GenToS). For a given list of candidate genes, GenToS calculates an appropriate statistical significance threshold and then searches for trait-associated variants in summary statistics from human GWAS. It thereby allows for identifying trait-associated genetic variants that do not meet genome-wide significance. The program additionally tests for enrichment of significant candidate gene associations2016-01-01T00:00:00Z20162026-05-04T15:07:23.823Z2019-03-26T22:48:06ZS-EPMC50177552761217510.1371/journal.pone.0162466