{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yuan G"],"funding":["NIDA NIH HHS","National Institute on Drug Abuse"],"pagination":["4857-4860"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5018461"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(19)"],"pubmed_abstract":["To prompt the development of (18)F-labeled positron emission tomography (PET) tracers for the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, we have prepared (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile ([(18)F]8). The radiosynthesis was achieved by a one-pot two-step method that utilized a spirocyclic hypervalent iodine(III) mediated radiofluorination to prepare the (18)F-labeled 1-bromo-3-fluorobenzene ([(18)F]15) intermediate with K(18)F. A subsequent copper(I) iodide mediated coupling reaction was carried out with 2-(2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile (10) to [(18)F]8 in 10±2% uncorrected radiochemical yield relative to starting (18)F-fluoride with >99% radiochemical purity and 29.6±7"],"journal":["Bioorganic & medicinal chemistry letters"],"pubmed_title":["Radiosynthesis and preliminary PET evaluation of (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors."],"pmcid":["PMC5018461"],"funding_grant_id":["K01 DA038000","DA038000"],"pubmed_authors":["Liang SH","Vasdev N","Jones GB","Yuan G"],"additional_accession":[]},"is_claimable":false,"name":"Radiosynthesis and preliminary PET evaluation of (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors.","description":"To prompt the development of (18)F-labeled positron emission tomography (PET) tracers for the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, we have prepared (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile ([(18)F]8). The radiosynthesis was achieved by a one-pot two-step method that utilized a spirocyclic hypervalent iodine(III) mediated radiofluorination to prepare the (18)F-labeled 1-bromo-3-fluorobenzene ([(18)F]15) intermediate with K(18)F. A subsequent copper(I) iodide mediated coupling reaction was carried out with 2-(2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile (10) to [(18)F]8 in 10±2% uncorrected radiochemical yield relative to starting (18)F-fluoride with >99% radiochemical purity and 29.6±7","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2025-04-19T07:40:38.289Z","creation":"2019-03-27T02:23:54Z"},"accession":"S-EPMC5018461","cross_references":{"pubmed":["27546294"],"doi":["10.1016/j.bmcl.2016.07.078"]}}