biostudies-literatureAraos RNational Institute of Allergy and Infectious DiseasesDiane Belfer Program for Human Microbial Ecology (M. J. B.)Becas Chile, Comision Nacional de Investigacion Cientifica y TecnologicaNIDDK NIH HHSNIAID NIH HHSNational Institutes of Health, Gobierno de Chile937-943https://www.ebi.ac.uk/biostudies/studies/S-EPMC5019285biostudies-literatureUnknown63(7)<h4>Background</h4>The emergence and dissemination of multidrug-resistant organisms (MDROs) is a global threat. Characterizing the human microbiome among hospitalized patients and identifying unique microbial signatures among those patients who acquire MDROs may identify novel infection prevention strategies.<h4>Methods</h4>Adult patients admitted to 5 general medical-surgical floors at a 649-bed, tertiary care center in Boston, Massachusetts, were classified according to in-hospital antimicrobial exposure and MDRO colonization status. Within 48 hours of hospital admission (baseline) and at discharge (follow-up), rectal swab samples were obtained, and compared with samples from an external control group of healthy persons from the community. DNA was extracted from samples, next-generation Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaPredominance of Lactobacillus spp. Among Patients Who Do Not Acquire Multidrug-Resistant Organisms.PMC5019285K24 AI119158R01 DK090989Tai AKBlaser MJSnyder GMAraos RD'Agata EMCfalsePredominance of Lactobacillus spp. Among Patients Who Do Not Acquire Multidrug-Resistant Organisms.<h4>Background</h4>The emergence and dissemination of multidrug-resistant organisms (MDROs) is a global threat. Characterizing the human microbiome among hospitalized patients and identifying unique microbial signatures among those patients who acquire MDROs may identify novel infection prevention strategies.<h4>Methods</h4>Adult patients admitted to 5 general medical-surgical floors at a 649-bed, tertiary care center in Boston, Massachusetts, were classified according to in-hospital antimicrobial exposure and MDRO colonization status. Within 48 hours of hospital admission (baseline) and at discharge (follow-up), rectal swab samples were obtained, and compared with samples from an external control group of healthy persons from the community. DNA was extracted from samples, next-generation 2016-01-01T00:00:00Z2016 Oct2026-07-15T23:57:44.241Z2019-03-27T02:23:58ZS-EPMC50192852735835010.1093/cid/ciw426