{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Baird A"],"funding":["National Cancer Institute","NCI NIH HHS","National Institute of General Medical Sciences"],"pagination":["602-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5021143"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(3)"],"pubmed_abstract":["In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human-specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human-specific signaling pathways in experimental models of injury and infers that a selection of human-specific genes, driven in part by the response to injury, may have facilitated the emergence of multifunctional genes expressed in other tissues."],"journal":["Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society"],"pubmed_title":["Injury, inflammation and the emergence of human-specific genes."],"pmcid":["PMC5021143"],"funding_grant_id":["NIGM78421","R01 CA170140","CA170140"],"pubmed_authors":["Baird A","Coimbra R","Costantini T","Eliceiri BP"],"additional_accession":[]},"is_claimable":false,"name":"Injury, inflammation and the emergence of human-specific genes.","description":"In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human-specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human-specific signaling pathways in experimental models of injury and infers that a selection of human-specific genes, driven in part by the response to injury, may have facilitated the emergence of multifunctional genes expressed in other tissues.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2025-04-25T18:16:54.544Z","creation":"2020-11-19T11:17:09Z"},"accession":"S-EPMC5021143","cross_references":{"pubmed":["26874655"],"doi":["10.1111/wrr.12422"]}}