biostudies-literatureBaird ANational Cancer InstituteNCI NIH HHSNational Institute of General Medical Sciences602-6https://www.ebi.ac.uk/biostudies/studies/S-EPMC5021143biostudies-literatureUnknown24(3)In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human-specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human-specific signaling pathways in experimental models of injury and infers that a selection of human-specific genes, driven in part by the response to injury, may have facilitated the emergence of multifunctional genes expressed in other tissues.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyInjury, inflammation and the emergence of human-specific genes.PMC5021143NIGM78421R01 CA170140CA170140Baird ACoimbra RCostantini TEliceiri BPfalseInjury, inflammation and the emergence of human-specific genes.In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human-specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human-specific signaling pathways in experimental models of injury and infers that a selection of human-specific genes, driven in part by the response to injury, may have facilitated the emergence of multifunctional genes expressed in other tissues.2016-01-01T00:00:00Z2016 May2025-04-25T18:16:54.544Z2020-11-19T11:17:09ZS-EPMC50211432687465510.1111/wrr.12422