{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Picard M"],"funding":["Natural Sciences and Engineering Research Council of Canada","Simon Foundation","NIDDK NIH HHS","NINDS NIH HHS","NIH","Canadian Institutes of Health Research","NIH HHS","The Warthon Fund","CIHR"],"pagination":["105-16"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5023480"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30"],"pubmed_abstract":["Once considered exclusively the cell's powerhouse, mitochondria are now recognized to perform multiple essential functions beyond energy production, impacting most areas of cell biology and medicine. Since the emergence of molecular biology and the discovery of pathogenic mitochondrial DNA defects in the 1980's, research advances have revealed a number of common human diseases which share an underlying pathogenesis involving mitochondrial dysfunction. Mitochondria undergo function-defining dynamic shape changes, communicate with each other, regulate gene expression within the nucleus, modulate synaptic transmission within the brain, release molecules that contribute to oncogenic transformation and trigger inflammatory responses systemically, and influence the regulation of complex physiolo"],"journal":["Mitochondrion"],"pubmed_title":["The rise of mitochondria in medicine."],"pmcid":["PMC5023480"],"funding_grant_id":["R33-CA182384","R01-DK73691","R01 OD010944","R01-OD10944","R01 DK073691","MFE274188","MOP136999","RGPIN/261864-2010","R01 NS021328","205844","R01-NS21328"],"pubmed_authors":["Burelle Y","Wallace DC","Picard M"],"additional_accession":[]},"is_claimable":false,"name":"The rise of mitochondria in medicine.","description":"Once considered exclusively the cell's powerhouse, mitochondria are now recognized to perform multiple essential functions beyond energy production, impacting most areas of cell biology and medicine. Since the emergence of molecular biology and the discovery of pathogenic mitochondrial DNA defects in the 1980's, research advances have revealed a number of common human diseases which share an underlying pathogenesis involving mitochondrial dysfunction. Mitochondria undergo function-defining dynamic shape changes, communicate with each other, regulate gene expression within the nucleus, modulate synaptic transmission within the brain, release molecules that contribute to oncogenic transformation and trigger inflammatory responses systemically, and influence the regulation of complex physiolo","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2026-04-08T02:22:04.986Z","creation":"2019-03-27T02:24:15Z"},"accession":"S-EPMC5023480","cross_references":{"pubmed":["27423788"],"doi":["10.1016/j.mito.2016.07.003"]}}