{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim H"],"funding":["National Mango Board. RHD is supported by P01","NCRR NIH HHS","NIEHS NIH HHS","National Cancer Institute","NCI NIH HHS","NIH HHS"],"pagination":["1912-23"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5026564"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["60(9)"],"pubmed_abstract":["Scope
Tannin-rich fruits have been evaluated as alternative prevention strategies for colorectal cancer based on their anti-inflammatory properties. This study compared tannin-rich preparations from mango (rich in gallotannins) and pomegranate (rich in ellagitannins) in the dextran sodium sulfate-induced colitis model.Methods and results
In rats, mango and pomegranate beverages decreased intestinal inflammation and the levels of pro-inflammatory cytokines in mucosa and serum. The mango beverage suppressed the ratio of phosphorylated/total protein expression of the IGF-1R-AKT/mTOR axis and downregulated mRNA expression of Igf1, Insr, and pik3cv. Pomegranate decreased p70S6K and RPS6, as well as Rps6ka2, Map2k2, and Mapk1 mRNA. In silico modeling indicated a high binding of d"],"journal":["Molecular nutrition & food research"],"pubmed_title":["Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis."],"pmcid":["PMC5026564"],"funding_grant_id":["CA090890","ES023512","T32 RR031229","T32 OD011083","P30 ES023512","P01 CA090890"],"pubmed_authors":["Mertens-Talcott SU","Dashwood RH","Pfent CM","Bisson WH","Kim H","Talcott ST","Ivanov I","Prudhomme KR","Banerjee N"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.","description":"Scope
Tannin-rich fruits have been evaluated as alternative prevention strategies for colorectal cancer based on their anti-inflammatory properties. This study compared tannin-rich preparations from mango (rich in gallotannins) and pomegranate (rich in ellagitannins) in the dextran sodium sulfate-induced colitis model.Methods and results
In rats, mango and pomegranate beverages decreased intestinal inflammation and the levels of pro-inflammatory cytokines in mucosa and serum. The mango beverage suppressed the ratio of phosphorylated/total protein expression of the IGF-1R-AKT/mTOR axis and downregulated mRNA expression of Igf1, Insr, and pik3cv. Pomegranate decreased p70S6K and RPS6, as well as Rps6ka2, Map2k2, and Mapk1 mRNA. In silico modeling indicated a high binding of d","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2025-06-01T02:50:09.002Z","creation":"2025-06-01T02:50:09.002Z"},"accession":"S-EPMC5026564","cross_references":{"pubmed":["27028006"],"doi":["10.1002/mnfr.201501008"]}}