biostudies-literatureKim HNational Mango Board. RHD is supported by P01NCRR NIH HHSNIEHS NIH HHSNational Cancer InstituteNCI NIH HHSNIH HHS1912-23https://www.ebi.ac.uk/biostudies/studies/S-EPMC5026564biostudies-literatureUnknown60(9)<h4>Scope</h4>Tannin-rich fruits have been evaluated as alternative prevention strategies for colorectal cancer based on their anti-inflammatory properties. This study compared tannin-rich preparations from mango (rich in gallotannins) and pomegranate (rich in ellagitannins) in the dextran sodium sulfate-induced colitis model.<h4>Methods and results</h4>In rats, mango and pomegranate beverages decreased intestinal inflammation and the levels of pro-inflammatory cytokines in mucosa and serum. The mango beverage suppressed the ratio of phosphorylated/total protein expression of the IGF-1R-AKT/mTOR axis and downregulated mRNA expression of Igf1, Insr, and pik3cv. Pomegranate decreased p70S6K and RPS6, as well as Rps6ka2, Map2k2, and Mapk1 mRNA. In silico modeling indicated a high binding of dMolecular nutrition & food researchComparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.PMC5026564CA090890ES023512T32 RR031229T32 OD011083P30 ES023512P01 CA090890Mertens-Talcott SUDashwood RHPfent CMBisson WHKim HTalcott STIvanov IPrudhomme KRBanerjee NfalseComparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.<h4>Scope</h4>Tannin-rich fruits have been evaluated as alternative prevention strategies for colorectal cancer based on their anti-inflammatory properties. This study compared tannin-rich preparations from mango (rich in gallotannins) and pomegranate (rich in ellagitannins) in the dextran sodium sulfate-induced colitis model.<h4>Methods and results</h4>In rats, mango and pomegranate beverages decreased intestinal inflammation and the levels of pro-inflammatory cytokines in mucosa and serum. The mango beverage suppressed the ratio of phosphorylated/total protein expression of the IGF-1R-AKT/mTOR axis and downregulated mRNA expression of Igf1, Insr, and pik3cv. Pomegranate decreased p70S6K and RPS6, as well as Rps6ka2, Map2k2, and Mapk1 mRNA. In silico modeling indicated a high binding of d2016-01-01T00:00:00Z2016 Sep2025-06-01T02:50:09.002Z2025-06-01T02:50:09.002ZS-EPMC50265642702800610.1002/mnfr.201501008