{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ebert LM"],"funding":["National Heart Foundation of Australia","National Health and Medical Research Council"],"pagination":["463-86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5026727"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(4)"],"pubmed_abstract":["Desmogleins (DSG) are a family of cadherin adhesion proteins that were first identified in desmosomes and provide cardiomyocytes and epithelial cells with the junctional stability to tolerate mechanical stress. However, one member of this family, DSG2, is emerging as a protein with additional biological functions on a broader range of cells. Here we reveal that DSG2 is expressed by non-desmosome-forming human endothelial progenitor cells as well as their mature counterparts [endothelial cells (ECs)] in human tissue from healthy individuals and cancer patients. Analysis of normal blood and bone marrow showed that DSG2 is also expressed by CD34(+)CD45(dim) hematopoietic progenitor cells. An inability to detect other desmosomal components, i.e., DSG1, DSG3 and desmocollin (DSC)2/3, on these c"],"journal":["Angiogenesis"],"pubmed_title":["A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis."],"pmcid":["PMC5026727"],"funding_grant_id":["GNT1022150","CR10A4983"],"pubmed_authors":["Betterman KL","Peng A","Shackleton M","Zannettino AC","Tan LY","Ruszkiewicz A","Lopez AF","Johan MZ","Min KK","Cockshell MP","Gronthos S","Szeto P","Koblar S","Silva L","Zhang Y","Harvey NL","Boyle S","Bonder CS","Ebert LM","Parham KA"],"additional_accession":[]},"is_claimable":false,"name":"A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis.","description":"Desmogleins (DSG) are a family of cadherin adhesion proteins that were first identified in desmosomes and provide cardiomyocytes and epithelial cells with the junctional stability to tolerate mechanical stress. However, one member of this family, DSG2, is emerging as a protein with additional biological functions on a broader range of cells. Here we reveal that DSG2 is expressed by non-desmosome-forming human endothelial progenitor cells as well as their mature counterparts [endothelial cells (ECs)] in human tissue from healthy individuals and cancer patients. Analysis of normal blood and bone marrow showed that DSG2 is also expressed by CD34(+)CD45(dim) hematopoietic progenitor cells. An inability to detect other desmosomal components, i.e., DSG1, DSG3 and desmocollin (DSC)2/3, on these c","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2026-05-03T19:23:50.693Z","creation":"2019-03-27T02:24:30Z"},"accession":"S-EPMC5026727","cross_references":{"pubmed":["27338829"],"doi":["10.1007/s10456-016-9520-y"]}}