{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Greco SH"],"funding":["NIDDK NIH HHS","NCI NIH HHS"],"pagination":["2816-27"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5026929"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["197(7)"],"pubmed_abstract":["Con A hepatitis is regarded as a T cell-mediated model of acute liver injury. Mincle is a C-type lectin receptor that is critical in the immune response to mycobacteria and fungi but does not have a well-defined role in preclinical models of non-pathogen-mediated inflammation. Because Mincle can ligate the cell death ligand SAP130, we postulated that Mincle signaling drives intrahepatic inflammation and liver injury in Con A hepatitis. Acute liver injury was assessed in the murine Con A hepatitis model using C57BL/6, Mincle(-/-), and Dectin-1(-/-) mice. The role of C/EBPβ and hypoxia-inducible factor-1α (HIF-1α) signaling was assessed using selective inhibitors. We found that Mincle was highly expressed in hepatic innate inflammatory cells and endothelial cells in both mice and humans. Fur"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Mincle Signaling Promotes Con A Hepatitis."],"pmcid":["PMC5026929"],"funding_grant_id":["R01 CA168611","T32 CA193111","K08 DK085278"],"pubmed_authors":["Katz SC","Nagaraj SV","Nikifrov Y","Whiteman C","Ochi A","Miller G","Kalabin A","Ravirala S","Daley D","Mani VR","Seifert L","Tejada K","Gutierrez J","Barilla R","Rokosh R","Salyana MA","Greco SH","Deutsch M","Hundeyin M","Gelb BE","Torres-Hernandez A"],"additional_accession":[]},"is_claimable":false,"name":"Mincle Signaling Promotes Con A Hepatitis.","description":"Con A hepatitis is regarded as a T cell-mediated model of acute liver injury. Mincle is a C-type lectin receptor that is critical in the immune response to mycobacteria and fungi but does not have a well-defined role in preclinical models of non-pathogen-mediated inflammation. Because Mincle can ligate the cell death ligand SAP130, we postulated that Mincle signaling drives intrahepatic inflammation and liver injury in Con A hepatitis. Acute liver injury was assessed in the murine Con A hepatitis model using C57BL/6, Mincle(-/-), and Dectin-1(-/-) mice. The role of C/EBPβ and hypoxia-inducible factor-1α (HIF-1α) signaling was assessed using selective inhibitors. We found that Mincle was highly expressed in hepatic innate inflammatory cells and endothelial cells in both mice and humans. Fur","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2025-04-04T01:07:14.715Z","creation":"2019-03-27T02:24:31Z"},"accession":"S-EPMC5026929","cross_references":{"pubmed":["27559045"],"doi":["10.4049/jimmunol.1600598"]}}