biostudies-literatureGreco SHNIDDK NIH HHSNCI NIH HHS2816-27https://www.ebi.ac.uk/biostudies/studies/S-EPMC5026929biostudies-literatureUnknown197(7)Con A hepatitis is regarded as a T cell-mediated model of acute liver injury. Mincle is a C-type lectin receptor that is critical in the immune response to mycobacteria and fungi but does not have a well-defined role in preclinical models of non-pathogen-mediated inflammation. Because Mincle can ligate the cell death ligand SAP130, we postulated that Mincle signaling drives intrahepatic inflammation and liver injury in Con A hepatitis. Acute liver injury was assessed in the murine Con A hepatitis model using C57BL/6, Mincle(-/-), and Dectin-1(-/-) mice. The role of C/EBPβ and hypoxia-inducible factor-1α (HIF-1α) signaling was assessed using selective inhibitors. We found that Mincle was highly expressed in hepatic innate inflammatory cells and endothelial cells in both mice and humans. FurJournal of immunology (Baltimore, Md. : 1950)Mincle Signaling Promotes Con A Hepatitis.PMC5026929R01 CA168611T32 CA193111K08 DK085278Katz SCNagaraj SVNikifrov YWhiteman COchi AMiller GKalabin ARavirala SDaley DMani VRSeifert LTejada KGutierrez JBarilla RRokosh RSalyana MAGreco SHDeutsch MHundeyin MGelb BETorres-Hernandez AfalseMincle Signaling Promotes Con A Hepatitis.Con A hepatitis is regarded as a T cell-mediated model of acute liver injury. Mincle is a C-type lectin receptor that is critical in the immune response to mycobacteria and fungi but does not have a well-defined role in preclinical models of non-pathogen-mediated inflammation. Because Mincle can ligate the cell death ligand SAP130, we postulated that Mincle signaling drives intrahepatic inflammation and liver injury in Con A hepatitis. Acute liver injury was assessed in the murine Con A hepatitis model using C57BL/6, Mincle(-/-), and Dectin-1(-/-) mice. The role of C/EBPβ and hypoxia-inducible factor-1α (HIF-1α) signaling was assessed using selective inhibitors. We found that Mincle was highly expressed in hepatic innate inflammatory cells and endothelial cells in both mice and humans. Fur2016-01-01T00:00:00Z2016 Oct2025-04-04T01:07:14.715Z2019-03-27T02:24:31ZS-EPMC50269292755904510.4049/jimmunol.1600598