{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["87(11)"],"submitter":["Arrambide G"],"pubmed_abstract":["Objective
To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual.Methods
Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who remained as CIS during a 2-year minimum follow-up (CIS-CIS). We determined levels of neurofascin, semaphorin 3A, fetuin A, glial fibrillary acidic protein, and neurofilament light (NfL) and heavy chains in CSF (estimated mean [95% confidence interval; CI]). We evaluated associations between biomarker levels, conversion, disability, and magnetic resonance parameters. In the replication phase, we determined NfL levels (n = 155) using a 900 ng/L cutoff. Primary en"],"journal":["Neurology"],"pagination":["1076-84"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5027802"],"repository":["biostudies-literature"],"pubmed_title":["Neurofilament light chain level is a weak risk factor for the development of MS."],"pmcid":["PMC5027802"],"pubmed_authors":["Tur C","Vidal-Jordana A","Comabella M","Eixarch H","Kuhle J","Galan I","Alvarez-Cermeno JC","Sastre-Garriga J","Picon C","Nos C","Pareto D","Rovira A","Villar LM","Auger C","Tintore M","Arrambide G","Espejo C","Rio J","Kappos L","Montalban X","Arevalo MJ","Disanto G","Simon E","Castillo J"],"additional_accession":[]},"is_claimable":false,"name":"Neurofilament light chain level is a weak risk factor for the development of MS.","description":"Objective
To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual.Methods
Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who remained as CIS during a 2-year minimum follow-up (CIS-CIS). We determined levels of neurofascin, semaphorin 3A, fetuin A, glial fibrillary acidic protein, and neurofilament light (NfL) and heavy chains in CSF (estimated mean [95% confidence interval; CI]). We evaluated associations between biomarker levels, conversion, disability, and magnetic resonance parameters. In the replication phase, we determined NfL levels (n = 155) using a 900 ng/L cutoff. Primary en","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2026-06-11T04:11:09.582Z","creation":"2025-05-18T10:29:11.821Z"},"accession":"S-EPMC5027802","cross_references":{"pubmed":["27521440"],"doi":["10.1212/WNL.0000000000003085"]}}