biostudies-literatureUnknown87(11)Arrambide G<h4>Objective</h4>To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual.<h4>Methods</h4>Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who remained as CIS during a 2-year minimum follow-up (CIS-CIS). We determined levels of neurofascin, semaphorin 3A, fetuin A, glial fibrillary acidic protein, and neurofilament light (NfL) and heavy chains in CSF (estimated mean [95% confidence interval; CI]). We evaluated associations between biomarker levels, conversion, disability, and magnetic resonance parameters. In the replication phase, we determined NfL levels (n = 155) using a 900 ng/L cutoff. Primary enNeurology1076-84https://www.ebi.ac.uk/biostudies/studies/S-EPMC5027802biostudies-literatureNeurofilament light chain level is a weak risk factor for the development of MS.PMC5027802Tur CVidal-Jordana AComabella MEixarch HKuhle JGalan IAlvarez-Cermeno JCSastre-Garriga JPicon CNos CPareto DRovira AVillar LMAuger CTintore MArrambide GEspejo CRio JKappos LMontalban XArevalo MJDisanto GSimon ECastillo JfalseNeurofilament light chain level is a weak risk factor for the development of MS.<h4>Objective</h4>To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual.<h4>Methods</h4>Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who remained as CIS during a 2-year minimum follow-up (CIS-CIS). We determined levels of neurofascin, semaphorin 3A, fetuin A, glial fibrillary acidic protein, and neurofilament light (NfL) and heavy chains in CSF (estimated mean [95% confidence interval; CI]). We evaluated associations between biomarker levels, conversion, disability, and magnetic resonance parameters. In the replication phase, we determined NfL levels (n = 155) using a 900 ng/L cutoff. Primary en2016-01-01T00:00:00Z2016 Sep2026-06-11T04:11:09.582Z2025-05-18T10:29:11.821ZS-EPMC50278022752144010.1212/WNL.0000000000003085