{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lambert Emo K"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS"],"pagination":["e1005881"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5028057"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(9)"],"pubmed_abstract":["During a primary influenza infection, cytotoxic CD8+ T cells need to infiltrate the infected airways and engage virus-infected epithelial cells. The factors that regulate T cell motility in the infected airway tissue are not well known. To more precisely study T cell infiltration of the airways, we developed an experimental model system using the trachea as a site where live imaging can be performed. CD8+ T cell motility was dynamic with marked changes in motility on different days of the infection. In particular, significant changes in average cell velocity and confinement were evident on days 8-10 during which the T cells abruptly but transiently increase velocity on day 9. Experiments to distinguish whether infection itself or antigen affect motility revealed that it is antigen, not act"],"journal":["PLoS pathogens"],"pubmed_title":["Live Imaging of Influenza Infection of the Trachea Reveals Dynamic Regulation of CD8+ T Cell Motility by Antigen."],"pmcid":["PMC5028057"],"funding_grant_id":["1P01 AI102851-O1A1","P01 AI102851","HHSN272201200005C","HHSN272201400005C"],"pubmed_authors":["Barilla C","Fowell D","Hyun YM","Topham DJ","Lambert Emo K","Gerber S","Kim M","Reilly E"],"additional_accession":[]},"is_claimable":false,"name":"Live Imaging of Influenza Infection of the Trachea Reveals Dynamic Regulation of CD8+ T Cell Motility by Antigen.","description":"During a primary influenza infection, cytotoxic CD8+ T cells need to infiltrate the infected airways and engage virus-infected epithelial cells. The factors that regulate T cell motility in the infected airway tissue are not well known. To more precisely study T cell infiltration of the airways, we developed an experimental model system using the trachea as a site where live imaging can be performed. CD8+ T cell motility was dynamic with marked changes in motility on different days of the infection. In particular, significant changes in average cell velocity and confinement were evident on days 8-10 during which the T cells abruptly but transiently increase velocity on day 9. Experiments to distinguish whether infection itself or antigen affect motility revealed that it is antigen, not act","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2025-04-05T15:57:18.789Z","creation":"2019-03-26T22:45:03Z"},"accession":"S-EPMC5028057","cross_references":{"pubmed":["27644089"],"doi":["10.1371/journal.ppat.1005881"]}}