{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Schein A"],"pubmed_abstract":["Mammalian genomes encode numerous natural antisense long noncoding RNAs (lncRNAs) that regulate gene expression. Recently, an antisense lncRNA to mouse Ubiquitin carboxyl-terminal hydrolase L1 (Uchl1) was reported to increase UCHL1 protein synthesis, representing a new functional class of lncRNAs, designated as SINEUPs, for SINE element-containing translation UP-regulators. Here, we show that an antisense lncRNA to the human protein phosphatase 1 regulatory subunit 12A (PPP1R12A), named as R12A-AS1, which overlaps with the 5' UTR and first coding exon of the PPP1R12A mRNA, functions as a SINEUP, increasing PPP1R12A protein translation in human cells. The SINEUP activity depends on the aforementioned sense-antisense interaction and a free right Alu monomer repeat element at the 3' end of R1"],"journal":["Scientific reports"],"pagination":["33605"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5028707"],"repository":["biostudies-literature"],"pubmed_title":["Identification of antisense long noncoding RNAs that function as SINEUPs in human cells."],"pmcid":["PMC5028707"],"pubmed_authors":["Schein A","Kauppinen S","Carninci P","Gustincich S","Zucchelli S"],"additional_accession":[]},"is_claimable":false,"name":"Identification of antisense long noncoding RNAs that function as SINEUPs in human cells.","description":"Mammalian genomes encode numerous natural antisense long noncoding RNAs (lncRNAs) that regulate gene expression. Recently, an antisense lncRNA to mouse Ubiquitin carboxyl-terminal hydrolase L1 (Uchl1) was reported to increase UCHL1 protein synthesis, representing a new functional class of lncRNAs, designated as SINEUPs, for SINE element-containing translation UP-regulators. Here, we show that an antisense lncRNA to the human protein phosphatase 1 regulatory subunit 12A (PPP1R12A), named as R12A-AS1, which overlaps with the 5' UTR and first coding exon of the PPP1R12A mRNA, functions as a SINEUP, increasing PPP1R12A protein translation in human cells. The SINEUP activity depends on the aforementioned sense-antisense interaction and a free right Alu monomer repeat element at the 3' end of R1","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2026-05-03T23:00:37.946Z","creation":"2019-03-27T02:24:39Z"},"accession":"S-EPMC5028707","cross_references":{"pubmed":["27646849"],"doi":["10.1038/srep33605"]}}