biostudies-literatureTai NNCATS NIH HHSNIDDK NIH HHSIacocca Family FoundationJuvenile Diabetes Research FoundationNational Institutes of Health2129-46https://www.ebi.ac.uk/biostudies/studies/S-EPMC5030808biostudies-literatureUnknown213(10)Both animal model and human studies indicate that commensal bacteria may modify type 1 diabetes (T1D) development. However, the underlying mechanisms by which gut microbes could trigger or protect from diabetes are not fully understood, especially the interaction of commensal bacteria with pathogenic CD8 T cells. In this study, using islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-reactive CD8 T cell receptor NY8.3 transgenic nonobese diabetic mice, we demonstrated that MyD88 strongly modulates CD8(+) T cell-mediated T1D development via the gut microbiota. Some microbial protein peptides share significant homology with IGRP. Both the microbial peptide mimic of Fusobacteria and the bacteria directly activate IGRP-specific NY8.3 T cells and promote diabetes deveThe Journal of experimental medicineMicrobial antigen mimics activate diabetogenic CD8 T cells in NOD mice.PMC5030808DK100500P30 DK045735R01 DK092882DK092882R01 DK100500DK0881812015-136P30 DK945735UL1 TR001863R01 DK088181Hu YWen LTai NZhang XChen LWong FSGulden EPeng JLiu FfalseMicrobial antigen mimics activate diabetogenic CD8 T cells in NOD mice.Both animal model and human studies indicate that commensal bacteria may modify type 1 diabetes (T1D) development. However, the underlying mechanisms by which gut microbes could trigger or protect from diabetes are not fully understood, especially the interaction of commensal bacteria with pathogenic CD8 T cells. In this study, using islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-reactive CD8 T cell receptor NY8.3 transgenic nonobese diabetic mice, we demonstrated that MyD88 strongly modulates CD8(+) T cell-mediated T1D development via the gut microbiota. Some microbial protein peptides share significant homology with IGRP. Both the microbial peptide mimic of Fusobacteria and the bacteria directly activate IGRP-specific NY8.3 T cells and promote diabetes deve2016-01-01T00:00:00Z2016 Sep2025-04-20T00:36:22.155Z2021-02-20T09:36:11ZS-EPMC50308082762141610.1084/jem.20160526