biostudies-literatureRodrigues FBWolfson FoundationEuropean Research CouncilMedical Research CouncilGlaxoSmithKline foundationKnut och Alice Wallenbergs StiftelseCHDI FoundationSwedish Research CouncilWellcome Truste0163479https://www.ebi.ac.uk/biostudies/studies/S-EPMC5033331biostudies-literatureUnknown11(9)<h4>Introduction</h4>Immune system activation is involved in Huntington's disease (HD) pathogenesis and biomarkers for this process could be relevant to study the disease and characterise the therapeutic response to specific interventions. We aimed to study inflammatory cytokines and microglial markers in the CSF of HD patients.<h4>Methods</h4>CSF TNF-α, IL-1β, IL-6, IL-8, YKL-40, chitotriosidase, total tau and neurofilament light chain (NFL) from 23 mutation carriers and 14 healthy controls were assayed.<h4>Results</h4>CSF TNF-α and IL-1β were below the limit of detection. Mutation carriers had higher YKL-40 (p = 0.003), chitotriosidase (p = 0.015) and IL-6 (p = 0.041) than controls. YKL-40 significantly correlated with disease stage (p = 0.007), UHDRS total functional capacity score (r =PloS oneCerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington's Disease.PMC5033331MR/M008592/1200181/Z/15/ZMR/L02053X/1Rodrigues FBWild EJTabrizi SJByrne LMZetterberg HRobertson NMcColgan PfalseCerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington's Disease.<h4>Introduction</h4>Immune system activation is involved in Huntington's disease (HD) pathogenesis and biomarkers for this process could be relevant to study the disease and characterise the therapeutic response to specific interventions. We aimed to study inflammatory cytokines and microglial markers in the CSF of HD patients.<h4>Methods</h4>CSF TNF-α, IL-1β, IL-6, IL-8, YKL-40, chitotriosidase, total tau and neurofilament light chain (NFL) from 23 mutation carriers and 14 healthy controls were assayed.<h4>Results</h4>CSF TNF-α and IL-1β were below the limit of detection. Mutation carriers had higher YKL-40 (p = 0.003), chitotriosidase (p = 0.015) and IL-6 (p = 0.041) than controls. YKL-40 significantly correlated with disease stage (p = 0.007), UHDRS total functional capacity score (r =2016-01-01T00:00:00Z20162025-04-25T19:24:29.473Z2019-03-26T22:48:13ZS-EPMC50333312765773010.1371/journal.pone.0163479