biostudies-literatureBittar CFAPESP158https://www.ebi.ac.uk/biostudies/studies/S-EPMC5034531biostudies-literatureUnknown13(1)<h4>Background</h4>Culex Flavivirus (CxFV) is an insect-specific virus that is widely distributed and primarily infects mosquito species from the genus Culex. Its hosts include Culex tritaeniorhynchus, Culex quinquefasciatus, and Anopheles sinensis mosquitoes. Since its original identification, CxFV has been reported in several countries. Despite the increasing number of reports on CxFV, little is known about its genomic characteristics. It is unclear whether the phylogenetic relationships between the strains are influenced by host species and geographic location.<h4>Results</h4>We characterized the Brazilian CxFV strain and performed a comprehensive genetic and phylogenetic characterization of CxFV based on all ORF sequences described so far. Our results revealed that the Brazilian strainVirology journalGenome sequencing and genetic characterization of Culex Flavirirus (CxFV) provides new information about its genotypes.PMC50345312013/21719-3Ullmann LSNogueira MLVedovello DBittar CMachado DCRahal PAraujo Junior JPfalseGenome sequencing and genetic characterization of Culex Flavirirus (CxFV) provides new information about its genotypes.<h4>Background</h4>Culex Flavivirus (CxFV) is an insect-specific virus that is widely distributed and primarily infects mosquito species from the genus Culex. Its hosts include Culex tritaeniorhynchus, Culex quinquefasciatus, and Anopheles sinensis mosquitoes. Since its original identification, CxFV has been reported in several countries. Despite the increasing number of reports on CxFV, little is known about its genomic characteristics. It is unclear whether the phylogenetic relationships between the strains are influenced by host species and geographic location.<h4>Results</h4>We characterized the Brazilian CxFV strain and performed a comprehensive genetic and phylogenetic characterization of CxFV based on all ORF sequences described so far. Our results revealed that the Brazilian strain2016-01-01T00:00:00Z2016 Sep2026-06-13T05:58:55.951Z2025-05-29T19:41:41.128ZS-EPMC50345312765862110.1186/s12985-016-0614-3