{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Morris O"],"funding":["Medical Research Council","Alzheimers Research UK","GE Healthcare","MRC"],"pagination":["120-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5034901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["116"],"pubmed_abstract":["2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [(18)F]RI-OR2-TAT has been measured in Wistar rats."],"journal":["Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine"],"pubmed_title":["Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide."],"pmcid":["PMC5034901"],"funding_grant_id":["MR/J012521/1","1233466","ARUK-PPG2012B-16"],"pubmed_authors":["Allan S","Grigg J","Prenant C","McMahon A","Morris O","Boutin H","Allsop D","Henderson F","Gregory J","Blykers A","Kadirvel M","Taylor M"],"additional_accession":[]},"is_claimable":false,"name":"Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide.","description":"2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [(18)F]RI-OR2-TAT has been measured in Wistar rats.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2025-04-21T19:19:41.845Z","creation":"2019-03-27T02:25:00Z"},"accession":"S-EPMC5034901","cross_references":{"pubmed":["27518217"],"doi":["10.1016/j.apradiso.2016.07.023"]}}