{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang L"],"funding":["HHS | National Institutes of Health","NICHD NIH HHS","NIGMS NIH HHS"],"pagination":["10583-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5035877"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["113(38)"],"pubmed_abstract":["The transcriptional repressor Capicua (Cic) controls tissue patterning and restricts organ growth, and has been recently implicated in several cancers. Cic has emerged as a primary sensor of signaling downstream of the receptor tyrosine kinase (RTK)/extracellular signal-regulated kinase (ERK) pathway, but how Cic activity is regulated in different cellular contexts remains poorly understood. We found that the kinase Minibrain (Mnb, ortholog of mammalian DYRK1A), acting through the adaptor protein Wings apart (Wap), physically interacts with and phosphorylates the Cic protein. Mnb and Wap inhibit Cic function by limiting its transcriptional repressor activity. Down-regulation of Cic by Mnb/Wap is necessary for promoting the growth of multiple organs, including the wings, eyes, and the brain"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua."],"pmcid":["PMC5035877"],"funding_grant_id":["R01 GM086537","R01 GM105813","GM105813","R01 HD085870","GM086537"],"pubmed_authors":["Shvartsman SY","Yang L","Veraksa A","Webster K","Paul S","Dent LG","Fores M","Jimenez G","Kondo S","Siegfried KR","Harvey K","Froldi F","Cheng L","Trieu KG"],"additional_accession":[]},"is_claimable":false,"name":"Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua.","description":"The transcriptional repressor Capicua (Cic) controls tissue patterning and restricts organ growth, and has been recently implicated in several cancers. Cic has emerged as a primary sensor of signaling downstream of the receptor tyrosine kinase (RTK)/extracellular signal-regulated kinase (ERK) pathway, but how Cic activity is regulated in different cellular contexts remains poorly understood. We found that the kinase Minibrain (Mnb, ortholog of mammalian DYRK1A), acting through the adaptor protein Wings apart (Wap), physically interacts with and phosphorylates the Cic protein. Mnb and Wap inhibit Cic function by limiting its transcriptional repressor activity. Down-regulation of Cic by Mnb/Wap is necessary for promoting the growth of multiple organs, including the wings, eyes, and the brain","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2025-04-04T09:22:03.032Z","creation":"2019-03-27T02:25:04Z"},"accession":"S-EPMC5035877","cross_references":{"pubmed":["27601662"],"doi":["10.1073/pnas.1609417113"]}}