biostudies-literatureUnknown71(10)Masa JF<h4>Background</h4>Non-invasive ventilation (NIV) is an effective form of treatment in patients with obesity hypoventilation syndrome (OHS) who have concomitant severe obstructive sleep apnoea (OSA). However, there is a paucity of evidence on the efficacy of NIV in patients with OHS without severe OSA. We performed a multicentre randomised clinical trial to determine the comparative efficacy of NIV versus lifestyle modification (control group) using daytime arterial carbon dioxide tension (PaCO2) as the main outcome measure.<h4>Methods</h4>Between May 2009 and December 2014 we sequentially screened patients with OHS without severe OSA. Participants were randomised to NIV versus lifestyle modification and were followed for 2 months. Arterial blood gas parameters, clinical symptoms, health-rThorax899-906https://www.ebi.ac.uk/biostudies/studies/S-EPMC5036235biostudies-literatureNon-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea.PMC5036235Ojeda EGonzalez MSancho-Chust JNCaballero CGallego BEgea CAlonso-Alvarez MLMarin JMTeran-Santos JSpanish Sleep NetworkMartinez-Martinez MAMunoz-Mendez JRamon MASenent CMasa JFChiner ECarrizo SJCorral JGomez-Garcia TDiaz-Cambriles TOrdax EGolpe RBarrot EMarti SGarcia-Ledesma ESanchez-Gomez JMokhlesi BRibas-Solis FJRomero ALopez-Martin SBengoa MCantalejo OBenitez JMGonzalez-Mangado NDiaz-de-Atauri JTroncoso MFSanchez-Quiroga MADe Lucas PGomez SPallero MMiranda ESantiago-Recuerda AfalseNon-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea.<h4>Background</h4>Non-invasive ventilation (NIV) is an effective form of treatment in patients with obesity hypoventilation syndrome (OHS) who have concomitant severe obstructive sleep apnoea (OSA). However, there is a paucity of evidence on the efficacy of NIV in patients with OHS without severe OSA. We performed a multicentre randomised clinical trial to determine the comparative efficacy of NIV versus lifestyle modification (control group) using daytime arterial carbon dioxide tension (PaCO2) as the main outcome measure.<h4>Methods</h4>Between May 2009 and December 2014 we sequentially screened patients with OHS without severe OSA. Participants were randomised to NIV versus lifestyle modification and were followed for 2 months. Arterial blood gas parameters, clinical symptoms, health-r2016-01-01T00:00:00Z2016 Oct2026-06-08T06:48:23.324Z2026-06-08T03:14:04.911ZS-EPMC50362352740616510.1136/thoraxjnl-2016-208501