biostudies-literatureZhang CNational Institute of General Medical SciencesNIGMS NIH HHS15668-71https://www.ebi.ac.uk/biostudies/studies/S-EPMC5039010biostudies-literatureUnknown137(50)An enantioselective, intermolecular dehydrogenative Heck arylation of trisubstituted alkenes to construct remote quaternary stereocenters has been developed. Using a new chiral pyridine oxazoline ligand, good to high enantioselectivity is achieved for various combinations of indole derivatives and trisubstituted alkenes. However, some combinations of substrates led to lower enantioselectivity, which provided the impetus to use structure enantioselectivity correlations to design a better performing ligand.Journal of the American Chemical SocietyEnantioselective Dehydrogenative Heck Arylations of Trisubstituted Alkenes with Indoles to Construct Quaternary Stereocenters.PMC5039010R01GM063540R01 GM063540Crawford JMSantiago CBSigman MSZhang CfalseEnantioselective Dehydrogenative Heck Arylations of Trisubstituted Alkenes with Indoles to Construct Quaternary Stereocenters.An enantioselective, intermolecular dehydrogenative Heck arylation of trisubstituted alkenes to construct remote quaternary stereocenters has been developed. Using a new chiral pyridine oxazoline ligand, good to high enantioselectivity is achieved for various combinations of indole derivatives and trisubstituted alkenes. However, some combinations of substrates led to lower enantioselectivity, which provided the impetus to use structure enantioselectivity correlations to design a better performing ligand.2015-01-01T00:00:00Z2015 Dec2024-11-14T16:08:02.813Z2019-03-27T02:25:14ZS-EPMC50390102662423610.1021/jacs.5b11335