{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sengupta A"],"funding":["NHGRI NIH HHS","NCI NIH HHS","NINDS NIH HHS"],"pagination":["E23"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5041122"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(3)"],"pubmed_abstract":["Oscillations in circadian metabolism are crucial to the well being of organism. Our understanding of metabolic rhythms has been greatly enhanced by recent advances in high-throughput systems biology experimental techniques and data analysis. In an in vitro setting, metabolite rhythms can be measured by time-dependent sampling over an experimental period spanning one or more days at sufficent resolution to elucidate rhythms. We hypothesized that cellular metabolic effects over such a time course would be influenced by both oscillatory and circadian-independent cell metabolic effects. Here we use nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling of mammalian cell culture media of synchronized U2 OS cells containing an intact transcriptional clock. The experiment was con"],"journal":["Metabolites"],"pubmed_title":["Deciphering the Duality of Clock and Growth Metabolism in a Cell Autonomous System Using NMR Profiling of the Secretome."],"pmcid":["PMC5041122"],"funding_grant_id":["R01 CA051497","R01 NS054794","T32 HG000046"],"pubmed_authors":["Van Dang C","Weljie AM","Olarerin-George AO","Krishnaiah SY","Growe J","Venkataraman A","Rhoades S","Slaff B","Sengupta A","Hogenesch JB"],"additional_accession":[]},"is_claimable":false,"name":"Deciphering the Duality of Clock and Growth Metabolism in a Cell Autonomous System Using NMR Profiling of the Secretome.","description":"Oscillations in circadian metabolism are crucial to the well being of organism. Our understanding of metabolic rhythms has been greatly enhanced by recent advances in high-throughput systems biology experimental techniques and data analysis. In an in vitro setting, metabolite rhythms can be measured by time-dependent sampling over an experimental period spanning one or more days at sufficent resolution to elucidate rhythms. We hypothesized that cellular metabolic effects over such a time course would be influenced by both oscillatory and circadian-independent cell metabolic effects. Here we use nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling of mammalian cell culture media of synchronized U2 OS cells containing an intact transcriptional clock. The experiment was con","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jul","modification":"2026-07-09T10:19:02.153Z","creation":"2025-06-01T12:39:47.247Z"},"accession":"S-EPMC5041122","cross_references":{"pubmed":["27472375"],"doi":["10.3390/metabo6030023"]}}