biostudies-literatureBalazard FMinistère de la Santé (FR)INSERMNovo NordiskMiinistère de l&apos;environnment (FR)1021https://www.ebi.ac.uk/biostudies/studies/S-EPMC5041527biostudies-literatureUnknown16(1)<h4>Background</h4>The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D.<h4>Methods</h4>Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends of the patients. Parents were asked to fill a 845-item questionnaire investigating the child's environment before diagnosis. The analysis took into account the matching between cases and controls. A second analysis used propensity score methods.<h4>Results</h4>We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnut cocoa spread consumption, wasp andBMC public healthAssociation of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case-control study.PMC5041527Programme hospitalier de recherche clinique AOM08049Programme de recherche sur les perturbateurs endocriniensGueorguieva IBassil JCappoen JPValtat SOlivier FRichard OAncelle DTerral DChaillous LDervaux DPaoli ADufillot DKerlan VGuemas IDe Kerdanet MBenmahammed AGuillou AJan POilleau LLoeuille GAParlier GMonier ALe Luyer BBertrand AMLabay FDallavale FBarat PBaechler EDumont AGBalazard FBortoluzzi MNCoutant RNicolino MChatel CFBony-Trifunovic HJellimann SRigalleau VDubosclard EDucluzeau PHDubourg HPignol MLWielickzo MCLarger EGautier JFZelinsky-Gurung AVervel CRadet CLaloi-Michelin MBoniface CCombes-Moukhovsky METalon PLecomte PCohen JFournier SIsis-Diab collaborative groupReznic YZymmermann BMarcoux EGajdos VFargeot-Espaliat AStuckens CAtlan CRazafimahefa BSalet RPenformis ABockel DPKerouedan CBaron SValleron AJLukas CPiquemal RGuilhem IBougneres PLienhardt-Roussie ABenhamou PYLaisney NGuerin BTamboura APantalone LKurtz FMignot BKhoury JRaoulx MThevenieau DGourdy PYollin EMetz CCaudrelier SSignor CBLe Fur SPepin-Donat MClavel SPambou ASimonin GPriou-Guesdon MDesailloud RStheneur CNadalon SPopelard FWeill JBendifallah DBrossier JPJoubert FfalseAssociation of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case-control study.<h4>Background</h4>The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D.<h4>Methods</h4>Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends of the patients. Parents were asked to fill a 845-item questionnaire investigating the child's environment before diagnosis. The analysis took into account the matching between cases and controls. A second analysis used propensity score methods.<h4>Results</h4>We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnut cocoa spread consumption, wasp and2016-01-01T00:00:00Z2016 Sep2026-06-08T05:51:02.583Z2026-06-08T03:09:33.066ZS-EPMC50415272768260210.1186/s12889-016-3690-9