{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(18)"],"submitter":["Viudez A"],"pubmed_abstract":["Pancreatic neuroendocrine tumor (PanNET) is a neoplastic entity in which few prognostic factors are well-known. Here, we aimed to evaluate the prognostic significance of N-myc downstream-regulated gen-1 (NDRG-1), O6-methylguanine DNA methyltransferase (MGMT) and Pleckstrin homology-like domain family A member 3 (PHLDA-3) by immunohistochemistry (IHC) and methylation analysis in 92 patients with resected PanNET and follow-up longer than 24 months. In multivariate analyses, ki-67 and our immunohistochemistry prognostic score (IPS-based on MGMT, NDRG-1 and PHLDA-3 IHC expression) were independent prognostic factors for disease-free-survival (DFS), while age and IPS were independent prognostic factors for overall survival (OS). Our IPS could be a useful prognostic biomarker for recurrence and survival in patients following resection for PanNET."],"journal":["Oncotarget"],"pagination":["24950-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5041882"],"repository":["biostudies-literature"],"pubmed_title":["A new immunohistochemistry prognostic score (IPS) for recurrence and survival in resected pancreatic neuroendocrine tumors (PanNET)."],"pmcid":["PMC5041882"],"pubmed_authors":["Azad NS","Zahurak M","De Jesus-Acosta A","Viudez A","Carvalho FL","Maleki Z","Wolfgang CL","Stark A","Laheru D","Baylin S","Herman JG"],"additional_accession":[]},"is_claimable":false,"name":"A new immunohistochemistry prognostic score (IPS) for recurrence and survival in resected pancreatic neuroendocrine tumors (PanNET).","description":"Pancreatic neuroendocrine tumor (PanNET) is a neoplastic entity in which few prognostic factors are well-known. Here, we aimed to evaluate the prognostic significance of N-myc downstream-regulated gen-1 (NDRG-1), O6-methylguanine DNA methyltransferase (MGMT) and Pleckstrin homology-like domain family A member 3 (PHLDA-3) by immunohistochemistry (IHC) and methylation analysis in 92 patients with resected PanNET and follow-up longer than 24 months. In multivariate analyses, ki-67 and our immunohistochemistry prognostic score (IPS-based on MGMT, NDRG-1 and PHLDA-3 IHC expression) were independent prognostic factors for disease-free-survival (DFS), while age and IPS were independent prognostic factors for overall survival (OS). Our IPS could be a useful prognostic biomarker for recurrence and survival in patients following resection for PanNET.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2024-12-04T12:44:47.818Z","creation":"2019-03-27T02:25:29Z"},"accession":"S-EPMC5041882","cross_references":{"pubmed":["26894863"],"doi":["10.18632/oncotarget.7436"]}}