{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(18)"],"submitter":["Moraes L"],"pubmed_abstract":["We previously reported that ABI3 expression was decreased in thyroid cancer tissues and that ectopic expression of ABI3 in a follicular thyroid carcinoma cell line delayed cell cycle progression and inhibited cell proliferation, invasion, migration and tumor formation in athymic mice. These data indicated that ABI3 is a tumor suppressor gene; however the mechanism through which ABI3 is silenced in thyroid carcinomas is unknown. We here show that treatment of four follicular thyroid carcinoma cell lines with 5-aza-dC induced demethylation of a specific region of the ABI3 promoter and restored ABI3 expression. In contrast, 5-aza-dC treatment did not restore ABI3 expression in a non-thyroid cell line, suggesting a tissue-specific regulation. We additionally show that 8 CpG sites located withi"],"journal":["Oncotarget"],"pagination":["25960-70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5041957"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptional regulation of the potential tumor suppressor ABI3 gene in thyroid carcinomas: interplay between methylation and NKX2-1 availability."],"pmcid":["PMC5041957"],"pubmed_authors":["Rubio I","Cerutti JM","Moraes L","Galrao AL"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional regulation of the potential tumor suppressor ABI3 gene in thyroid carcinomas: interplay between methylation and NKX2-1 availability.","description":"We previously reported that ABI3 expression was decreased in thyroid cancer tissues and that ectopic expression of ABI3 in a follicular thyroid carcinoma cell line delayed cell cycle progression and inhibited cell proliferation, invasion, migration and tumor formation in athymic mice. These data indicated that ABI3 is a tumor suppressor gene; however the mechanism through which ABI3 is silenced in thyroid carcinomas is unknown. We here show that treatment of four follicular thyroid carcinoma cell lines with 5-aza-dC induced demethylation of a specific region of the ABI3 promoter and restored ABI3 expression. In contrast, 5-aza-dC treatment did not restore ABI3 expression in a non-thyroid cell line, suggesting a tissue-specific regulation. We additionally show that 8 CpG sites located withi","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2026-04-16T09:22:09.541Z","creation":"2019-03-27T02:25:30Z"},"accession":"S-EPMC5041957","cross_references":{"pubmed":["27036019"],"doi":["10.18632/oncotarget.8416"]}}