{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(18)"],"submitter":["Zhang XF"],"pubmed_abstract":["To examine the relationship between cytotoxic T lymphocyte antigen-4 (CTLA-4) expression and esophageal carcinoma prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded primary tumor specimens from 158 patients with esophageal cancer. CTLA-4 was detected in the cytoplasm and cell membranes of esophageal cancer cells and in interstitial lymphocytes. In univariate analyses (log-rank), higher interstitial CTLA-4+ lymphocyte density and higher tumor CTLA-4 expression were associated with shorter overall survival (OS). After controlling for age and clinical stage, multivariate analysis (Cox) found that tumor CTLA-4 expression was an independent predictor of shorter OS (HR 2.016, P = 0.004). These results indicate that CTLA-4 expression in the tumor environment (both lymphocytes and tumor cells) is associated with poorer prognosis. In addition, CTLA-4 profiles may be useful for predicting the benefits and toxicity of CTLA-4 blockade in patients with esophageal carcinoma."],"journal":["Oncotarget"],"pagination":["26670-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5042006"],"repository":["biostudies-literature"],"pubmed_title":["Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis."],"pmcid":["PMC5042006"],"pubmed_authors":["Chen CL","Pan QZ","Zhang HX","Li YQ","Zhao JJ","Zhang XF","Wang QJ","Xia JC","Liu Q","Pan K","Weng DS","Jiang SS"],"additional_accession":[]},"is_claimable":false,"name":"Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis.","description":"To examine the relationship between cytotoxic T lymphocyte antigen-4 (CTLA-4) expression and esophageal carcinoma prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded primary tumor specimens from 158 patients with esophageal cancer. CTLA-4 was detected in the cytoplasm and cell membranes of esophageal cancer cells and in interstitial lymphocytes. In univariate analyses (log-rank), higher interstitial CTLA-4+ lymphocyte density and higher tumor CTLA-4 expression were associated with shorter overall survival (OS). After controlling for age and clinical stage, multivariate analysis (Cox) found that tumor CTLA-4 expression was an independent predictor of shorter OS (HR 2.016, P = 0.004). These results indicate that CTLA-4 expression in the tumor environment (both lymphocytes and tumor cells) is associated with poorer prognosis. In addition, CTLA-4 profiles may be useful for predicting the benefits and toxicity of CTLA-4 blockade in patients with esophageal carcinoma.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2025-04-26T15:06:05.634Z","creation":"2019-03-27T02:25:30Z"},"accession":"S-EPMC5042006","cross_references":{"pubmed":["27050369"],"doi":["10.18632/oncotarget.8476"]}}