biostudies-literatureRosenkranz MANICHD NIH HHSNCCIH NIH HHSNIMH NIH HHSNational Center for Complementary and Integrative HealthAltermed Research FoundationEvjue FoundationNational Institute of Child Health and Human Development18-30https://www.ebi.ac.uk/biostudies/studies/S-EPMC5045317biostudies-literatureUnknown58<h4>Background</h4>Psychological stress has long been recognized as a contributing factor to asthma symptom expression and disease progression. Yet, the neural mechanisms that underlie this relationship have been largely unexplored in research addressing the pathophysiology and management of asthma. Studies that have examined the mechanisms of this relationship in the periphery suggest that it is the superimposition of acute stress on top of chronic stress that is of greatest concern for airway inflammation.<h4>Methods</h4>We compared asthmatic individuals with high and low levels of chronic life stress in their neural and peripheral physiological responses to the Trier Social Stress Test and a matched control task. We used FDG-PET to measure neural activity during performance of the two tBrain, behavior, and immunityMind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress.PMC5045317K01 AT006202K01-AT006202T32 MH018269T32 AT003997P30HD003352T32 AT006956P30 HD003352P01 AT004952Rosenkranz MACrisafi GChristian BTHiggins ATMoore SMSalk RHGresham LKBusse WWMoore MNEsnault SWeng HYDavidson RJfalseMind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress.<h4>Background</h4>Psychological stress has long been recognized as a contributing factor to asthma symptom expression and disease progression. Yet, the neural mechanisms that underlie this relationship have been largely unexplored in research addressing the pathophysiology and management of asthma. Studies that have examined the mechanisms of this relationship in the periphery suggest that it is the superimposition of acute stress on top of chronic stress that is of greatest concern for airway inflammation.<h4>Methods</h4>We compared asthmatic individuals with high and low levels of chronic life stress in their neural and peripheral physiological responses to the Trier Social Stress Test and a matched control task. We used FDG-PET to measure neural activity during performance of the two t2016-01-01T00:00:00Z2016 Nov2025-04-18T18:37:35.175Z2019-03-27T02:25:37ZS-EPMC50453172703924110.1016/j.bbi.2016.03.024