{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(5)"],"submitter":["Aaker JD"],"pubmed_abstract":["The transcriptional program that controls oligodendrocyte maturation and central nervous system (CNS) myelination has not been fully characterized. In this study, we use high-throughput RNA sequencing to analyze how the loss of a key transcription factor, zinc finger protein 191 (ZFP191), results in oligodendrocyte development abnormalities and CNS hypomyelination. Using a previously described mutant mouse that is deficient in ZFP191 protein expression (Zfp191<sup>null</sup>), we demonstrate that key transcripts are reduced in the whole brain as well as within oligodendrocyte lineage cells cultured in vitro To determine whether the loss of myelin seen in Zfp191<sup>null</sup> mice contributes indirectly to these perturbations, we also examined the transcriptome of a well-characterized mous"],"journal":["ASN neuro"],"pagination":["1759091416670749"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5046175"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi) Mice."],"pmcid":["PMC5046175"],"pubmed_authors":["Aaker JD","Looney TJ","Elbaz B","Zhang L","Lahn BT","Wu Y","Popko B"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi) Mice.","description":"The transcriptional program that controls oligodendrocyte maturation and central nervous system (CNS) myelination has not been fully characterized. In this study, we use high-throughput RNA sequencing to analyze how the loss of a key transcription factor, zinc finger protein 191 (ZFP191), results in oligodendrocyte development abnormalities and CNS hypomyelination. Using a previously described mutant mouse that is deficient in ZFP191 protein expression (Zfp191<sup>null</sup>), we demonstrate that key transcripts are reduced in the whole brain as well as within oligodendrocyte lineage cells cultured in vitro To determine whether the loss of myelin seen in Zfp191<sup>null</sup> mice contributes indirectly to these perturbations, we also examined the transcriptome of a well-characterized mous","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2026-04-07T17:54:40.434Z","creation":"2019-03-27T02:25:40Z"},"accession":"S-EPMC5046175","cross_references":{"pubmed":["27683878"],"doi":["10.1177/1759091416670749"]}}