biostudies-literatureUnknown8(5)Aaker JDThe transcriptional program that controls oligodendrocyte maturation and central nervous system (CNS) myelination has not been fully characterized. In this study, we use high-throughput RNA sequencing to analyze how the loss of a key transcription factor, zinc finger protein 191 (ZFP191), results in oligodendrocyte development abnormalities and CNS hypomyelination. Using a previously described mutant mouse that is deficient in ZFP191 protein expression (Zfp191^null), we demonstrate that key transcripts are reduced in the whole brain as well as within oligodendrocyte lineage cells cultured in vitro To determine whether the loss of myelin seen in Zfp191^null mice contributes indirectly to these perturbations, we also examined the transcriptome of a well-characterized mousASN neuro1759091416670749https://www.ebi.ac.uk/biostudies/studies/S-EPMC5046175biostudies-literatureTranscriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi) Mice.PMC5046175Aaker JDLooney TJElbaz BZhang LLahn BTWu YPopko BfalseTranscriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi) Mice.The transcriptional program that controls oligodendrocyte maturation and central nervous system (CNS) myelination has not been fully characterized. In this study, we use high-throughput RNA sequencing to analyze how the loss of a key transcription factor, zinc finger protein 191 (ZFP191), results in oligodendrocyte development abnormalities and CNS hypomyelination. Using a previously described mutant mouse that is deficient in ZFP191 protein expression (Zfp191^null), we demonstrate that key transcripts are reduced in the whole brain as well as within oligodendrocyte lineage cells cultured in vitro To determine whether the loss of myelin seen in Zfp191^null mice contributes indirectly to these perturbations, we also examined the transcriptome of a well-characterized mous2016-01-01T00:00:00Z2016 Oct2026-04-07T17:54:40.434Z2019-03-27T02:25:40ZS-EPMC50461752768387810.1177/1759091416670749