{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Darash-Yahana M"],"funding":["NIGMS NIH HHS"],"pagination":["10890-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5047192"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["113(39)"],"pubmed_abstract":["Iron-sulfur (Fe-S) proteins are thought to play an important role in cancer cells mediating redox reactions, DNA replication, and telomere maintenance. Nutrient-deprivation autophagy factor-1 (NAF-1) is a 2Fe-2S protein associated with the progression of multiple cancer types. It is unique among Fe-S proteins because of its 3Cys-1His cluster coordination structure that allows it to be relatively stable, as well as to transfer its clusters to apo-acceptor proteins. Here, we report that overexpression of NAF-1 in xenograft breast cancer tumors results in a dramatic augmentation in tumor size and aggressiveness and that NAF-1 overexpression enhances the tolerance of cancer cells to oxidative stress. Remarkably, overexpression of a NAF-1 mutant with a single point mutation that stabilizes the "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters."],"pmcid":["PMC5047192"],"funding_grant_id":["R01 GM101467"],"pubmed_authors":["Sohn YS","Jennings PA","Pikarsky E","Geiger T","Nechushtai R","Song L","Lu M","Karmi O","Darash-Yahana M","Mittler R","Pozniak Y","Tamir S","Onuchic JN","Bai F"],"additional_accession":[]},"is_claimable":false,"name":"Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters.","description":"Iron-sulfur (Fe-S) proteins are thought to play an important role in cancer cells mediating redox reactions, DNA replication, and telomere maintenance. Nutrient-deprivation autophagy factor-1 (NAF-1) is a 2Fe-2S protein associated with the progression of multiple cancer types. It is unique among Fe-S proteins because of its 3Cys-1His cluster coordination structure that allows it to be relatively stable, as well as to transfer its clusters to apo-acceptor proteins. Here, we report that overexpression of NAF-1 in xenograft breast cancer tumors results in a dramatic augmentation in tumor size and aggressiveness and that NAF-1 overexpression enhances the tolerance of cancer cells to oxidative stress. Remarkably, overexpression of a NAF-1 mutant with a single point mutation that stabilizes the ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2026-04-07T18:01:09.876Z","creation":"2019-03-27T02:25:42Z"},"accession":"S-EPMC5047192","cross_references":{"pubmed":["27621439"],"doi":["10.1073/pnas.1612736113"]}}