biostudies-literatureConroy ALKim Kertland; the Tesari FoundationCanada Research Chair in Molecular ParasitologyCanada Research Chair in Infectious Diseases and InflammationSandra Rotman Centre for Global HealthCanadian Institutes of Health Researchofw134https://www.ebi.ac.uk/biostudies/studies/S-EPMC5047396biostudies-literatureUnknown3(3)<b><i>Background.</i></b>  Host responses to infection are critical determinants of disease severity and clinical outcome. The development of tools to risk stratify children with malaria is needed to identify children most likely to benefit from targeted interventions. <b><i>Methods.</i></b>  This study investigated the kinetics of candidate biomarkers of mortality associated with endothelial activation and dysfunction (angiopoietin-2 [Ang-2], soluble FMS-like tyrosine kinase-1 [sFlt-1], and soluble intercellular adhesion molecule-1 [sICAM-1]) and inflammation (10 kDa interferon γ-induced protein [CXCL10/IP-10] and soluble triggering receptor expressed on myeloid cells-1 [sTREM-1]) in the context of a randomized, double-blind, placebo-controlled, parallel-arm trial evaluating inhaled nitriOpen forum infectious diseasesHost Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria.PMC5047396MOP-115160-13721-136813McDonald CRConroy ALKim HBarker KRJohn CCOpoka ROLiles WCHiggins SJNamasopo SHawkes MKain KCfalseHost Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria.<b><i>Background.</i></b>  Host responses to infection are critical determinants of disease severity and clinical outcome. The development of tools to risk stratify children with malaria is needed to identify children most likely to benefit from targeted interventions. <b><i>Methods.</i></b>  This study investigated the kinetics of candidate biomarkers of mortality associated with endothelial activation and dysfunction (angiopoietin-2 [Ang-2], soluble FMS-like tyrosine kinase-1 [sFlt-1], and soluble intercellular adhesion molecule-1 [sICAM-1]) and inflammation (10 kDa interferon γ-induced protein [CXCL10/IP-10] and soluble triggering receptor expressed on myeloid cells-1 [sTREM-1]) in the context of a randomized, double-blind, placebo-controlled, parallel-arm trial evaluating inhaled nitri2016-01-01T00:00:00Z2016 Sep2026-04-30T19:14:51.208Z2019-03-27T02:25:42ZS-EPMC50473962770399610.1093/ofid/ofw134