{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zota AR"],"funding":["NIEHS NIH HHS"],"pagination":["1521-1528"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5047792"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["124(10)"],"pubmed_abstract":["<h4>Background</h4>Phthalates and bisphenol A (BPA) are widely used industrial chemicals that may adversely impact human health. Human exposure is ubiquitous and can occur through diet, including consumption of processed or packaged food.<h4>Objective</h4>To examine associations between recent fast food intake and BPA and urinary metabolites of di(2-ethylhexyl) phthalate (?DEHPm) and diisononyl phthalate (DiNPm) among the U.S.<h4>Population</h4><h4>Methods</h4>We combined data on 8,877 participants from the National Health and Nutrition Examination Survey (NHANES 2003-2010). Using 24-hr dietary recall data, we quantified: a) fast food intake [percent of total energy intake (TEI) from fast food]; b) fast food-derived fat intake (percent of TEI from fat in fast food); and c) fast food intake by food group (dairy, eggs, grains, meat, and other). We examined associations between dietary exposures and urinary chemical concentrations using multivariate linear regression.<h4>Results</h4>We observed evidence of a positive, dose-response relationship between fast food intake and exposure to phthalates (p-trend < 0.0001) but not BPA; participants with high consumption (? 34.9% TEI from fast food) had 23.8% (95% CI: 11.9%, 36.9%) and 39.0% (95% CI: 21.9%, 58.5%) higher levels of ?DEHPm and DiNPm, respectively, than nonconsumers. Fast food-derived fat intake was also positively associated with ?DEHPm and DiNPm (p-trend < 0.0001). After adjusting for other food groups, ?DEHPm was associated with grain and other intake, and DiNPm was associated with meat and grain intake.<h4>Conclusion</h4>Fast food may be a source of exposure to DEHP and DiNP. These results, if confirmed, could inform individual and regulatory exposure reduction strategies.<h4>Citation</h4>Zota AR, Phillips CA, Mitro SD. 2016. Recent fast food consumption and bisphenol A and phthalates exposures among the U.S. population in NHANES, 2003-2010. Environ Health Perspect 124:1521-1528;?http://dx.doi.org/10.1289/ehp.1510803."],"journal":["Environmental health perspectives"],"pubmed_title":["Recent Fast Food Consumption and Bisphenol A and Phthalates Exposures among the U.S. Population in NHANES, 2003-2010."],"pmcid":["PMC5047792"],"funding_grant_id":["R00 ES019881","K99 ES019881"],"pubmed_authors":["Zota AR","Phillips CA","Mitro SD"],"additional_accession":[]},"is_claimable":false,"name":"Recent Fast Food Consumption and Bisphenol A and Phthalates Exposures among the U.S. Population in NHANES, 2003-2010.","description":"<h4>Background</h4>Phthalates and bisphenol A (BPA) are widely used industrial chemicals that may adversely impact human health. Human exposure is ubiquitous and can occur through diet, including consumption of processed or packaged food.<h4>Objective</h4>To examine associations between recent fast food intake and BPA and urinary metabolites of di(2-ethylhexyl) phthalate (?DEHPm) and diisononyl phthalate (DiNPm) among the U.S.<h4>Population</h4><h4>Methods</h4>We combined data on 8,877 participants from the National Health and Nutrition Examination Survey (NHANES 2003-2010). Using 24-hr dietary recall data, we quantified: a) fast food intake [percent of total energy intake (TEI) from fast food]; b) fast food-derived fat intake (percent of TEI from fat in fast food); and c) fast food intake by food group (dairy, eggs, grains, meat, and other). We examined associations between dietary exposures and urinary chemical concentrations using multivariate linear regression.<h4>Results</h4>We observed evidence of a positive, dose-response relationship between fast food intake and exposure to phthalates (p-trend < 0.0001) but not BPA; participants with high consumption (? 34.9% TEI from fast food) had 23.8% (95% CI: 11.9%, 36.9%) and 39.0% (95% CI: 21.9%, 58.5%) higher levels of ?DEHPm and DiNPm, respectively, than nonconsumers. Fast food-derived fat intake was also positively associated with ?DEHPm and DiNPm (p-trend < 0.0001). After adjusting for other food groups, ?DEHPm was associated with grain and other intake, and DiNPm was associated with meat and grain intake.<h4>Conclusion</h4>Fast food may be a source of exposure to DEHP and DiNP. These results, if confirmed, could inform individual and regulatory exposure reduction strategies.<h4>Citation</h4>Zota AR, Phillips CA, Mitro SD. 2016. Recent fast food consumption and bisphenol A and phthalates exposures among the U.S. population in NHANES, 2003-2010. Environ Health Perspect 124:1521-1528;?http://dx.doi.org/10.1289/ehp.1510803.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2021-03-18T09:09:13Z","creation":"2019-03-27T02:25:43Z"},"accession":"S-EPMC5047792","cross_references":{"pubmed":["27072648"],"doi":["10.1289/ehp.1510803"]}}