{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["High M"],"funding":["NIEHS NIH HHS"],"pagination":["73-84"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5049919"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["<h4>Background</h4>Respiratory syncytial virus (RSV) is the global leading cause of lower respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease including bronchiolitis, but susceptibility mechanisms remain unclear.<h4>Methods</h4>We infected a panel of 30 inbred strains of mice with RSV and measured changes in lung disease parameters 1 and 5days post-infection and they were used in genome-wide association (GWA) studies to identify quantitative trait loci (QTL) and susceptibility gene candidates.<h4>Findings</h4>GWA identified QTLs for RSV disease phenotypes, and the innate immunity scavenger receptor Marco was a candidate susceptibility gene; targeted deletion of Marco worsened murine RSV disease. We characterized a human MARCO promoter SNP that "],"journal":["EBioMedicine"],"pubmed_title":["Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants."],"pmcid":["PMC5049919"],"funding_grant_id":["P30 ES010126"],"pubmed_authors":["Marzec J","Wiltshire T","Bell DA","Shi M","Kobzik L","Cho HY","Caballero MT","Suzuki O","Kleeberger SR","Miller-DeGraff L","McCaw ZR","Weinberg C","High M","Serra ME","Wang X","Gladwell W","Acosta PL","Ciencewicki J","Verhein KC","Polack FP","Peden DB"],"additional_accession":[]},"is_claimable":false,"name":"Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants.","description":"<h4>Background</h4>Respiratory syncytial virus (RSV) is the global leading cause of lower respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease including bronchiolitis, but susceptibility mechanisms remain unclear.<h4>Methods</h4>We infected a panel of 30 inbred strains of mice with RSV and measured changes in lung disease parameters 1 and 5days post-infection and they were used in genome-wide association (GWA) studies to identify quantitative trait loci (QTL) and susceptibility gene candidates.<h4>Findings</h4>GWA identified QTLs for RSV disease phenotypes, and the innate immunity scavenger receptor Marco was a candidate susceptibility gene; targeted deletion of Marco worsened murine RSV disease. We characterized a human MARCO promoter SNP that ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2026-05-01T01:50:43.335Z","creation":"2019-03-27T02:25:50Z"},"accession":"S-EPMC5049919","cross_references":{"pubmed":["27554839"],"doi":["10.1016/j.ebiom.2016.08.011"]}}