{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zamboni V"],"funding":["Telethon"],"pagination":["34877"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5054378"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["During brain development, the small GTPases Rac1/Rac3 play key roles in neuronal migration, neuritogenesis, synaptic formation and plasticity, via control of actin cytoskeleton dynamic. Their activity is positively and negatively regulated by GEFs and GAPs molecules, respectively. However their in vivo roles are poorly known. The ArhGAP15 gene, coding for a Rac-specific GAP protein, is expressed in both excitatory and inhibitory neurons of the adult hippocampus, and its loss results in the hyperactivation of Rac1/Rac3. In the CA3 and dentate gyrus (DG) regions of the ArhGAP15 mutant hippocampus the CR+, PV+ and SST+ inhibitory neurons are reduced in number, due to reduced efficiency and directionality of their migration, while pyramidal neurons are unaffected. Loss of ArhGAP15 alters neuri"],"journal":["Scientific reports"],"pubmed_title":["Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits."],"pmcid":["PMC5054378"],"funding_grant_id":["GGP11097","GGP14106"],"pubmed_authors":["Gavello D","Hirsch E","de Curtis I","Armentano M","El-Assawi N","Ferri N","Passafaro M","D'Adamo P","Bianchi V","Mauro A","Merlo GR","Carabelli V","Zamboni V","Umbach A","Valnegri P","Ghigo A","Saro G","Germena G","Priano L","Ciraolo E"],"additional_accession":[]},"is_claimable":false,"name":"Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.","description":"During brain development, the small GTPases Rac1/Rac3 play key roles in neuronal migration, neuritogenesis, synaptic formation and plasticity, via control of actin cytoskeleton dynamic. Their activity is positively and negatively regulated by GEFs and GAPs molecules, respectively. However their in vivo roles are poorly known. The ArhGAP15 gene, coding for a Rac-specific GAP protein, is expressed in both excitatory and inhibitory neurons of the adult hippocampus, and its loss results in the hyperactivation of Rac1/Rac3. In the CA3 and dentate gyrus (DG) regions of the ArhGAP15 mutant hippocampus the CR+, PV+ and SST+ inhibitory neurons are reduced in number, due to reduced efficiency and directionality of their migration, while pyramidal neurons are unaffected. Loss of ArhGAP15 alters neuri","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2025-04-26T20:46:51.95Z","creation":"2019-03-27T02:26:09Z"},"accession":"S-EPMC5054378","cross_references":{"pubmed":["27713499"],"doi":["10.1038/srep34877"]}}