{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tarantini S"],"funding":["National Institute of Neurological Disorders and Stroke","NCCIH NIH HHS","NIA NIH HHS","NINDS NIH HHS","National Center for Complementary and Alternative Medicine","National Institute of General Medical Sciences","National Institute on Aging","NIGMS NIH HHS"],"pagination":["239-258"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5061677"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(4)"],"pubmed_abstract":["Epidemiological findings support the concept of Developmental Origins of Health and Disease, suggesting that early-life hormonal influences during a sensitive period of development have a fundamental impact on vascular health later in life. The endocrine changes that occur during development are highly conserved across mammalian species and include dramatic increases in circulating IGF-1 levels during adolescence. The present study was designed to characterize the effect of developmental IGF-1 deficiency on the vascular aging phenotype. To achieve that goal, early-onset endocrine IGF-1 deficiency was induced in mice by knockdown of IGF-1 in the liver using Cre-lox technology (Igf1 <sup>f/f</sup> mice crossed with mice expressing albumin-driven Cre recombinase). This model exhibits low-circ"],"journal":["Age (Dordrecht, Netherlands)"],"pubmed_title":["IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis."],"pmcid":["PMC5061677"],"funding_grant_id":["R01 AT006526","U54 GM104938","NS056218","R01 AG038747","R01 NS056218","AT006526","R01 AG055395","AG031085","P30 AG050911","5U54GM104938","P30 AG028718","R01 AG047879","K08 AG031085","AG038747"],"pubmed_authors":["Valcarcel-Ares MN","Tarantini S","Wei JY","Sonntag WE","Csiszar A","Ashpole NM","Giles CB","Wren JD","Ungvari Z"],"additional_accession":[]},"is_claimable":false,"name":"IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.","description":"Epidemiological findings support the concept of Developmental Origins of Health and Disease, suggesting that early-life hormonal influences during a sensitive period of development have a fundamental impact on vascular health later in life. The endocrine changes that occur during development are highly conserved across mammalian species and include dramatic increases in circulating IGF-1 levels during adolescence. The present study was designed to characterize the effect of developmental IGF-1 deficiency on the vascular aging phenotype. To achieve that goal, early-onset endocrine IGF-1 deficiency was induced in mice by knockdown of IGF-1 in the liver using Cre-lox technology (Igf1 <sup>f/f</sup> mice crossed with mice expressing albumin-driven Cre recombinase). This model exhibits low-circ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Aug","modification":"2025-05-29T19:41:05.376Z","creation":"2025-05-29T19:41:05.376Z"},"accession":"S-EPMC5061677","cross_references":{"pubmed":["27566308"],"doi":["10.1007/s11357-016-9943-9"]}}