{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shinoda Y"],"funding":["Smoking Research Foundation","Ministry of Education, Science, Sports and Culture of Japan","Research Fellowship from the Japan Society for the Promotion of Science"],"pagination":["e0163992"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5065174"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(10)"],"pubmed_abstract":["Cardiovascular diseases are risk factors for depression in humans. We recently proposed that σ1 receptor (σ1R) stimulation rescued cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC) in mice. Importantly, σ1R stimulation reportedly ameliorates depression-like behaviors in rodents. Thus, we hypothesized that impaired σ1R activity in brain triggers depression-like behaviors in animals with cardiovascular disease. Indeed, here we found that cardiac hypertrophy and heart failure induced by TAC were associated with depression-like behaviors concomitant with downregulation of σ1R expression in brain 6 weeks after surgery. σ1R levels significantly decreased in astrocytes in both the hippocampal CA1 region and dentate gyrus. Oral administration of the specific σ1R"],"journal":["PloS one"],"pubmed_title":["Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression."],"pmcid":["PMC5065174"],"funding_grant_id":["25293124","26102704","265570"],"pubmed_authors":["Shinoda Y","Hasegawa H","Zhang C","Bhuiyan MS","Kanai H","Tagashira H","Han F","Fukunaga K"],"additional_accession":[]},"is_claimable":false,"name":"Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression.","description":"Cardiovascular diseases are risk factors for depression in humans. We recently proposed that σ1 receptor (σ1R) stimulation rescued cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC) in mice. Importantly, σ1R stimulation reportedly ameliorates depression-like behaviors in rodents. Thus, we hypothesized that impaired σ1R activity in brain triggers depression-like behaviors in animals with cardiovascular disease. Indeed, here we found that cardiac hypertrophy and heart failure induced by TAC were associated with depression-like behaviors concomitant with downregulation of σ1R expression in brain 6 weeks after surgery. σ1R levels significantly decreased in astrocytes in both the hippocampal CA1 region and dentate gyrus. Oral administration of the specific σ1R","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2026-04-07T13:30:38.062Z","creation":"2019-03-26T22:51:06Z"},"accession":"S-EPMC5065174","cross_references":{"pubmed":["27741227"],"doi":["10.1371/journal.pone.0163992"]}}