{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kobeissy FH"],"funding":["BLRD VA","RRD VA","National Natural Science Foundation of China","NINDS NIH HHS","National Institutes of Health","U.S. Department of Veterans Affairs"],"pagination":["98"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5065984"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["<i>Emx1</i> has long been implicated in embryonic brain development. Previously we found that mice null of <i>Emx1</i> gene had smaller dentate gyri and reduced neurogenesis, although the molecular mechanisms underlying this defect was not well understood. To decipher the role of <i>Emx1</i> gene in neural regeneration and the timing of its involvement, we determine the frequency of neural stem cells (NSCs) in embryonic and adult forebrains of <i>Emx1</i> wild type (WT) and knock out (KO) mice in the neurosphere assay. <i>Emx1</i> gene deletion reduced the frequency and self-renewal capacity of NSCs of the embryonic brain but did not affect neuronal or glial differentiation. <i>Emx1</i> KO NSCs also exhibited a reduced migratory capacity in response to serum or vascular endothelial growth "],"journal":["Frontiers in molecular neuroscience"],"pubmed_title":["Deciphering the Role of <i>Emx1</i> in Neurogenesis: A Neuroproteomics Approach."],"pmcid":["PMC5065984"],"funding_grant_id":["I01 BX003335","81403479","R21 NS051576","I01RX000655","I01 RX000655","I01BX003335","R01 NS071050"],"pubmed_authors":["Kobeissy FH","Liu J","Fu S","Hansen K","Neumann M","Jin K"],"additional_accession":[]},"is_claimable":false,"name":"Deciphering the Role of <i>Emx1</i> in Neurogenesis: A Neuroproteomics Approach.","description":"<i>Emx1</i> has long been implicated in embryonic brain development. Previously we found that mice null of <i>Emx1</i> gene had smaller dentate gyri and reduced neurogenesis, although the molecular mechanisms underlying this defect was not well understood. To decipher the role of <i>Emx1</i> gene in neural regeneration and the timing of its involvement, we determine the frequency of neural stem cells (NSCs) in embryonic and adult forebrains of <i>Emx1</i> wild type (WT) and knock out (KO) mice in the neurosphere assay. <i>Emx1</i> gene deletion reduced the frequency and self-renewal capacity of NSCs of the embryonic brain but did not affect neuronal or glial differentiation. <i>Emx1</i> KO NSCs also exhibited a reduced migratory capacity in response to serum or vascular endothelial growth ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2026-04-12T20:21:38.087Z","creation":"2019-03-27T02:26:48Z"},"accession":"S-EPMC5065984","cross_references":{"pubmed":["27799894"],"doi":["10.3389/fnmol.2016.00098"]}}