biostudies-literatureKobeissy FHBLRD VARRD VANational Natural Science Foundation of ChinaNINDS NIH HHSNational Institutes of HealthU.S. Department of Veterans Affairs98https://www.ebi.ac.uk/biostudies/studies/S-EPMC5065984biostudies-literatureUnknown9<i>Emx1</i> has long been implicated in embryonic brain development. Previously we found that mice null of <i>Emx1</i> gene had smaller dentate gyri and reduced neurogenesis, although the molecular mechanisms underlying this defect was not well understood. To decipher the role of <i>Emx1</i> gene in neural regeneration and the timing of its involvement, we determine the frequency of neural stem cells (NSCs) in embryonic and adult forebrains of <i>Emx1</i> wild type (WT) and knock out (KO) mice in the neurosphere assay. <i>Emx1</i> gene deletion reduced the frequency and self-renewal capacity of NSCs of the embryonic brain but did not affect neuronal or glial differentiation. <i>Emx1</i> KO NSCs also exhibited a reduced migratory capacity in response to serum or vascular endothelial growth Frontiers in molecular neuroscienceDeciphering the Role of <i>Emx1</i> in Neurogenesis: A Neuroproteomics Approach.PMC5065984I01 BX00333581403479R21 NS051576I01RX000655I01 RX000655I01BX003335R01 NS071050Kobeissy FHLiu JFu SHansen KNeumann MJin KfalseDeciphering the Role of <i>Emx1</i> in Neurogenesis: A Neuroproteomics Approach.<i>Emx1</i> has long been implicated in embryonic brain development. Previously we found that mice null of <i>Emx1</i> gene had smaller dentate gyri and reduced neurogenesis, although the molecular mechanisms underlying this defect was not well understood. To decipher the role of <i>Emx1</i> gene in neural regeneration and the timing of its involvement, we determine the frequency of neural stem cells (NSCs) in embryonic and adult forebrains of <i>Emx1</i> wild type (WT) and knock out (KO) mice in the neurosphere assay. <i>Emx1</i> gene deletion reduced the frequency and self-renewal capacity of NSCs of the embryonic brain but did not affect neuronal or glial differentiation. <i>Emx1</i> KO NSCs also exhibited a reduced migratory capacity in response to serum or vascular endothelial growth 2016-01-01T00:00:00Z20162026-04-12T20:21:38.087Z2019-03-27T02:26:48ZS-EPMC50659842779989410.3389/fnmol.2016.00098