{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lilla EA"],"funding":["NIGMS NIH HHS"],"pagination":["905-907"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5069167"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(11)"],"pubmed_abstract":["Nikkomycins and polyoxins are antifungal peptidylnucleoside antibiotics active against human and plant pathogens. Here we report that during peptidylnucleoside biosynthesis in Streptomyces cacaoi and S. tendae, the C5' extension of the nucleoside essential for downstream structural diversification is catalyzed by a conserved radical S-adenosyl-L-methionine (SAM) enzyme, PolH or NikJ. This is distinct from the nucleophilic mechanism reported for antibacterial nucleosides and represents a new mechanism of nucleoside natural product biosynthesis."],"journal":["Nature chemical biology"],"pubmed_title":["Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes."],"pmcid":["PMC5069167"],"funding_grant_id":["R01 GM115729"],"pubmed_authors":["Lilla EA","Yokoyama K"],"additional_accession":[]},"is_claimable":false,"name":"Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes.","description":"Nikkomycins and polyoxins are antifungal peptidylnucleoside antibiotics active against human and plant pathogens. Here we report that during peptidylnucleoside biosynthesis in Streptomyces cacaoi and S. tendae, the C5' extension of the nucleoside essential for downstream structural diversification is catalyzed by a conserved radical S-adenosyl-L-methionine (SAM) enzyme, PolH or NikJ. This is distinct from the nucleophilic mechanism reported for antibacterial nucleosides and represents a new mechanism of nucleoside natural product biosynthesis.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2026-05-05T08:39:06.692Z","creation":"2019-03-27T02:27:02Z"},"accession":"S-EPMC5069167","cross_references":{"pubmed":["27642865"],"doi":["10.1038/nchembio.2187"]}}