{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Olsen HG"],"funding":["Research Council of Norway","Tine Norwegian Dairy Company","GENO Breeding and AI Organization"],"pagination":["79"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5072345"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(1)"],"pubmed_abstract":["<h4>Background</h4>Clinical mastitis is an inflammation of the mammary gland and causes significant costs to dairy production. It is unfavourably genetically correlated to milk production, and, thus, knowledge of the mechanisms that underlie these traits would be valuable to improve both of them simultaneously through breeding. A quantitative trait locus (QTL) that affects both clinical mastitis and milk production has recently been fine-mapped to around 89 Mb on bovine chromosome 6 (BTA6), but identification of the gene that underlies this QTL was not possible due to the strong linkage disequilibrium between single nucleotide polymorphisms (SNPs) within this region. Our aim was to identify the gene and, if possible, the causal polymorphism(s) responsible for this QTL through association a"],"journal":["Genetics, selection, evolution : GSE"],"pubmed_title":["Fine mapping of a QTL on bovine chromosome 6 using imputed full sequence data suggests a key role for the group-specific component (GC) gene in clinical mastitis and milk production."],"pmcid":["PMC5072345"],"funding_grant_id":["190489"],"pubmed_authors":["Lewandowska-Sabat AM","Nome T","Hansen HH","Dahl SR","Sodeland M","Grove H","Arnyasi M","Sundsaasen KK","Kent MP","Heringstad B","Olsaker I","Svendsen M","Knutsen TM","Olsen HG","Lien S"],"additional_accession":[]},"is_claimable":false,"name":"Fine mapping of a QTL on bovine chromosome 6 using imputed full sequence data suggests a key role for the group-specific component (GC) gene in clinical mastitis and milk production.","description":"<h4>Background</h4>Clinical mastitis is an inflammation of the mammary gland and causes significant costs to dairy production. It is unfavourably genetically correlated to milk production, and, thus, knowledge of the mechanisms that underlie these traits would be valuable to improve both of them simultaneously through breeding. A quantitative trait locus (QTL) that affects both clinical mastitis and milk production has recently been fine-mapped to around 89 Mb on bovine chromosome 6 (BTA6), but identification of the gene that underlies this QTL was not possible due to the strong linkage disequilibrium between single nucleotide polymorphisms (SNPs) within this region. Our aim was to identify the gene and, if possible, the causal polymorphism(s) responsible for this QTL through association a","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2026-06-06T22:41:48.802Z","creation":"2019-03-27T02:27:12Z"},"accession":"S-EPMC5072345","cross_references":{"pubmed":["27760518"],"doi":["10.1186/s12711-016-0257-2"]}}