{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["63(8)"],"submitter":["Aoki T"],"pubmed_abstract":["Programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD-L1 expression and tumor-infiltrating CD8(+) T cells in formalin-fixed, paraffin-embedded tumor specimens from 53 untreated pediatric patients with eight cancer types: neuroblastoma, extracranial malignant germ cell tumor, hepatoblastoma, germinoma, medulloblastoma, renal tumor, rhabdomyosarcoma, and atypical teratoid/rhabdoid tumor. One rhabdomyosarcoma with the shortest survival exhibited membranous PD-L1 expression and germinoma contained abundant tumor-infiltrating CD8(+) T cells and PD-L1-positive macrophages. The PD-1/PD-L1 pathway tended to be inactive in pediatric cancers."],"journal":["Pediatric blood & cancer"],"pagination":["1461-4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5074238"],"repository":["biostudies-literature"],"pubmed_title":["Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers."],"pmcid":["PMC5074238"],"pubmed_authors":["Hanada R","Kurihara J","Kishimoto H","Kawashima H","Hino M","Aoki T","Koh K","Motohashi S","Kyushiki M","Arakawa Y","Shimojo N"],"additional_accession":[]},"is_claimable":false,"name":"Low Frequency of Programmed Death Ligand 1 Expression in Pediatric Cancers.","description":"Programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD-L1 expression and tumor-infiltrating CD8(+) T cells in formalin-fixed, paraffin-embedded tumor specimens from 53 untreated pediatric patients with eight cancer types: neuroblastoma, extracranial malignant germ cell tumor, hepatoblastoma, germinoma, medulloblastoma, renal tumor, rhabdomyosarcoma, and atypical teratoid/rhabdoid tumor. One rhabdomyosarcoma with the shortest survival exhibited membranous PD-L1 expression and germinoma contained abundant tumor-infiltrating CD8(+) T cells and PD-L1-positive macrophages. The PD-1/PD-L1 pathway tended to be inactive in pediatric cancers.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Aug","modification":"2025-06-01T12:02:49.123Z","creation":"2025-06-01T12:02:49.123Z"},"accession":"S-EPMC5074238","cross_references":{"pubmed":["27135656"],"doi":["10.1002/pbc.26018"]}}