biostudies-literatureUnknown6Cespedes MVIn the human endocrine system many protein hormones including urotensin, glucagon, obestatin, bombesin and secretin, among others, are supplied from amyloidal secretory granules. These granules form part of the so called functional amyloids, which within the whole aggregome appear to be more abundant than formerly believed. Bacterial inclusion bodies (IBs) are non-toxic, nanostructured functional amyloids whose biological fabrication can be tailored to render materials with defined biophysical properties. Since under physiological conditions they steadily release their building block protein in a soluble and functional form, IBs are considered as mimetics of endocrine secretory granules. We have explored here if the in vivo implantation of functional IBs in a given tissue would represent aScientific reports35765https://www.ebi.ac.uk/biostudies/studies/S-EPMC5075894biostudies-literatureBacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.PMC5075894Schwartz SAlamo PToledo-Rubio VVillaverde AMendoza RSanchez-Chardi AUnzueta UCespedes MVCorchero JLMangues RAbasolo IFernandez YVazquez EFerrer-Miralles NSeras-Franzoso JfalseBacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.In the human endocrine system many protein hormones including urotensin, glucagon, obestatin, bombesin and secretin, among others, are supplied from amyloidal secretory granules. These granules form part of the so called functional amyloids, which within the whole aggregome appear to be more abundant than formerly believed. Bacterial inclusion bodies (IBs) are non-toxic, nanostructured functional amyloids whose biological fabrication can be tailored to render materials with defined biophysical properties. Since under physiological conditions they steadily release their building block protein in a soluble and functional form, IBs are considered as mimetics of endocrine secretory granules. We have explored here if the in vivo implantation of functional IBs in a given tissue would represent a2016-01-01T00:00:00Z2016 Oct2025-04-04T09:20:48.288Z2019-03-27T02:27:21ZS-EPMC50758942777508310.1038/srep35765